Cell Senescence Entries for PAK2

Cell Types
Lung fibroblast
Cell Lines
IMR-90
Cancer Cell?
No
Method
Knockdown, Overexpression
Type of senescence
Oncogene-induced
Senescence Effect
Induces
Primary Reference
Lee et al. (2020) Pak2 kinase promotes cellular senescence and organismal aging. Proc Natl Acad Sci U S A 116(27)13311-13319 (PubMed)

PAK2 Gene Information

HGNC symbol
PAK2 
Aliases
PAK65; PAKgamma 
Common name
p21 (RAC1) activated kinase 2 
Entrez Id
5062
Description
The p21 activated kinases (PAK) are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. The PAK proteins are a family of serine/threonine kinases that serve as targets for the small GTP binding proteins, CDC42 and RAC1, and have been implicated in a wide range of biological activities. The protein encoded by this gene is activated by proteolytic cleavage during caspase-mediated apoptosis, and may play a role in regulating the apoptotic events in the dying cell. [provided by RefSeq, Jul 2008].

PAK2 Ontologies

Gene Ontology
Process: GO:6468; protein phosphorylation
GO:16310; phosphorylation
GO:43066; negative regulation of apoptotic process
GO:6915; apoptotic process
GO:42981; regulation of apoptotic process
GO:8152; metabolic process
GO:40008; regulation of growth
GO:61098; positive regulation of protein tyrosine kinase activity
GO:35556; intracellular signal transduction
GO:50731; positive regulation of peptidyl-tyrosine phosphorylation
GO:7165; signal transduction
And 19 more GO terms
Cellular component: GO:5737; cytoplasm
GO:5634; nucleus
GO:16020; membrane
GO:48471; perinuclear region of cytoplasm
GO:5886; plasma membrane
GO:5829; cytosol
GO:5911; cell-cell junction
GO:14069; postsynaptic density
GO:30141; secretory granule
GO:98978; glutamatergic synapse
Function: GO:166; nucleotide binding
GO:4672; protein kinase activity
GO:4674; protein serine/threonine kinase activity
GO:4712; protein serine/threonine/tyrosine kinase activity
GO:5524; ATP binding
GO:16301; kinase activity
GO:16740; transferase activity
GO:106310; protein serine kinase activity
GO:3824; catalytic activity
GO:5515; protein binding
GO:42802; identical protein binding
And 5 more GO terms
Show all GO terms

Homologs of PAK2 in Model Organisms

Caenorhabditis elegans
pak-1
Danio rerio
pak2a
Mus musculus
Pak2
Rattus norvegicus
Pak2
Schizosaccharomyces pombe
shk1

In other databases

GenAge model organism genes
  • A homolog of this gene for Caenorhabditis elegans is present as pak-1

External links

OMIM
605022
Ensembl
ENSG00000180370
Entrez Gene
5062
UniGene
518530
1000 Genomes
1000 Genomes
HPRD
GenAtlas
PAK2
GeneCards
PAK2