Cell Senescence Entries for PAK4

Cell Types
Embryonic kidney, Lung fibroblast
Cell Lines
HEK293T, IMR-90, MRC-5
Cancer Cell?
No
Method
Overexpression
Type of senescence
Unclear
Senescence Effect
Induces
Primary Reference
Ferrand et al. (2016) Screening of a kinase library reveals novel pro-senescence kinases and their common NF-κB-dependent transcriptional program. Aging (Albany NY) 7(11)986-1003 (PubMed)

PAK4 Gene Information

HGNC symbol
PAK4 
Aliases
 
Common name
p21 (RAC1) activated kinase 4 
Entrez Id
10298
Description
PAK proteins, a family of serine/threonine p21-activating kinases, include PAK1, PAK2, PAK3 and PAK4. PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. They serve as targets for the small GTP binding proteins Cdc42 and Rac and have been implicated in a wide range of biological activities. PAK4 interacts specifically with the GTP-bound form of Cdc42Hs and weakly activates the JNK family of MAP kinases. PAK4 is a mediator of filopodia formation and may play a role in the reorganization of the actin cytoskeleton. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

PAK4 Ontologies

Gene Ontology
Process: GO:6468; protein phosphorylation
GO:7049; cell cycle
GO:16310; phosphorylation
GO:6915; apoptotic process
GO:7165; signal transduction
GO:7010; cytoskeleton organization
GO:35556; intracellular signal transduction
GO:16477; cell migration
GO:1558; regulation of cell growth
GO:98609; cell-cell adhesion
GO:45766; positive regulation of angiogenesis
And 5 more GO terms
Cellular component: GO:5737; cytoplasm
GO:5925; focal adhesion
GO:5829; cytosol
GO:5912; adherens junction
GO:5794; Golgi apparatus
Function: GO:4674; protein serine/threonine kinase activity
GO:166; nucleotide binding
GO:4672; protein kinase activity
GO:4712; protein serine/threonine/tyrosine kinase activity
GO:5524; ATP binding
GO:16301; kinase activity
GO:16740; transferase activity
GO:106310; protein serine kinase activity
GO:5515; protein binding
GO:98641; cadherin binding involved in cell-cell adhesion
Show all GO terms

Homologs of PAK4 in Model Organisms

Danio rerio
pak4
Drosophila melanogaster
mbt
Mus musculus
Pak4
Rattus norvegicus
Pak4

External links

OMIM
605451
Ensembl
ENSG00000130669
Entrez Gene
10298
UniGene
20447
1000 Genomes
1000 Genomes
HPRD
GenAtlas
PAK4
GeneCards
PAK4