Cell Senescence Entries for PARK7

Cell Types
Endothelial progenitor
Cell Lines
Primary cell
Cancer Cell?
No
Method
Knockdown, Overexpression
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Han et al. (2018) DJ-1 Alleviates Angiotensin II-Induced Endothelial Progenitor Cell Damage by Activating the PPARĪ³/HO-1 Pathway. J Cell Biochem 119(1)392-400 (PubMed)

PARK7 Gene Information

HGNC symbol
PARK7 
Aliases
DJ-1; DJ1; GATD2 
Common name
Parkinsonism associated deglycase 
Entrez Id
11315
Description
The product of this gene belongs to the peptidase C56 family of proteins. It acts as a positive regulator of androgen receptor-dependent transcription. It may also function as a redox-sensitive chaperone, as a sensor for oxidative stress, and it apparently protects neurons against oxidative stress and cell death. Defects in this gene are the cause of autosomal recessive early-onset Parkinson disease 7. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008].

PARK7 Ontologies

Gene Ontology
Process: GO:6508; proteolysis
GO:6281; DNA repair
GO:6974; cellular response to DNA damage stimulus
GO:6914; autophagy
GO:6954; inflammatory response
GO:98869; cellular oxidant detoxification
GO:7338; single fertilization
GO:7005; mitochondrion organization
GO:50821; protein stabilization
GO:31334; positive regulation of protein-containing complex assembly
GO:51897; positive regulation of protein kinase B signaling
And 96 more GO terms
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:16020; membrane
GO:5783; endoplasmic reticulum
GO:5654; nucleoplasm
GO:5829; cytosol
GO:5886; plasma membrane
GO:5739; mitochondrion
GO:98793; presynapse
GO:45121; membrane raft
GO:45202; synapse
And 11 more GO terms
Function: GO:3723; RNA binding
GO:8233; peptidase activity
GO:16787; hydrolase activity
GO:42803; protein homodimerization activity
GO:5515; protein binding
GO:3729; mRNA binding
GO:5102; signaling receptor binding
GO:42802; identical protein binding
GO:45296; cadherin binding
GO:5507; copper ion binding
GO:45340; mercury ion binding
And 22 more GO terms
Show all GO terms

Homologs of PARK7 in Model Organisms

Caenorhabditis elegans
djr-1.2
Danio rerio
park7
Drosophila melanogaster
dj-1beta
Mus musculus
Park7
Rattus norvegicus
Park7
Schizosaccharomyces pombe
SPAC22E12.03c

In other databases

GenAge model organism genes
  • A homolog of this gene for Drosophila melanogaster is present as dj-1beta
LongevityMap
  • This gene is present as PARK7

External links

OMIM
602533
Ensembl
ENSG00000116288
Entrez Gene
11315
UniGene
419640
1000 Genomes
1000 Genomes
HPRD
GenAtlas
PARK7
GeneCards
PARK7