Cell Senescence Entries for PATZ1

Cell Types
Umbilical vein endothelial
Cell Lines
Primary cell
Cancer Cell?
No
Method
Knockdown, Overexpression
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Cho et al. (2012) POZ/BTB and AT-hook-containing zinc finger protein 1 (PATZ1) inhibits endothelial cell senescence through a p53 dependent pathway. Cell Death Differ 19(4)703-12 (PubMed)

PATZ1 Gene Information

HGNC symbol
PATZ1 
Aliases
dJ400N23; MAZR; PATZ; RIAZ; ZBTB19; ZNF278; ZSG 
Common name
POZ/BTB and AT hook containing zinc finger 1 
Entrez Id
23598
Description
The protein encoded by this gene contains an A-T hook DNA binding motif which usually binds to other DNA binding structures to play an important role in chromatin modeling and transcription regulation. Its Poz domain is thought to function as a site for protein-protein interaction and is required for transcriptional repression, and the zinc-fingers comprise the DNA binding domain. Since the encoded protein has typical features of a transcription factor, it is postulated to be a repressor of gene expression. In small round cell sarcoma, this gene is fused to EWS by a small inversion of 22q, then the hybrid is thought to be translocated (t(1;22)(p36.1;q12). The rearrangement of chromosome 22 involves intron 8 of EWS and exon 1 of this gene creating a chimeric sequence containing the transactivation domain of EWS fused to zinc finger domain of this protein. This is a distinct example of an intra-chromosomal rearrangement of chromosome 22. Four alternatively spliced transcript variants are described for this gene. [provided by RefSeq, Jul 2008].

PATZ1 Ontologies

Gene Ontology
Process: GO:6355; regulation of transcription, DNA-templated
GO:45892; negative regulation of transcription, DNA-templated
GO:7283; spermatogenesis
GO:8584; male gonad development
GO:10468; regulation of gene expression
GO:10596; negative regulation of endothelial cell migration
GO:30217; T cell differentiation
GO:45893; positive regulation of transcription, DNA-templated
GO:122; negative regulation of transcription by RNA polymerase II
GO:6357; regulation of transcription by RNA polymerase II
Cellular component: GO:5634; nucleus
GO:5654; nucleoplasm
Function: GO:46872; metal ion binding
GO:3677; DNA binding
GO:978; RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:3682; chromatin binding
GO:1227; DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:31625; ubiquitin protein ligase binding
GO:5515; protein binding
Show all GO terms

Homologs of PATZ1 in Model Organisms

Danio rerio
patz1
Mus musculus
Patz1
Rattus norvegicus
Patz1

External links

OMIM
605165
Ensembl
ENSG00000100105
Entrez Gene
23598
UniGene
731398
1000 Genomes
1000 Genomes
HPRD
GenAtlas
PATZ1
GeneCards
PATZ1