Cell Senescence Entries for PCGF2

Cell Types
Foreskin fibroblast, Lung fibroblast
Cell Lines
BJ, MRC-5, WI-38
Cancer Cell?
No
Method
Knockout, Overexpression
Type of senescence
Unclear
Senescence Effect
Induces
Primary Reference
Guo et al. (2007) Mel-18, a polycomb group protein, regulates cell proliferation and senescence via transcriptional repression of Bmi-1 and c-Myc oncoproteins. Mol Biol Cell 18(2)536-46 (PubMed)

PCGF2 Gene Information

HGNC symbol
PCGF2 
Aliases
MEL-18; RNF110; ZNF144 
Common name
polycomb group ring finger 2 
Entrez Id
7703
Description
The protein encoded by this gene contains a RING finger motif and is similar to the polycomb group (PcG) gene products. PcG gene products form complexes via protein-protein interaction and maintain the transcription repression of genes involved in embryogenesis, cell cycles, and tumorigenesis. This protein was shown to act as a negative regulator of transcription and has tumor suppressor activity. The expression of this gene was detected in various tumor cells, but is limited in neural organs in normal tissues. Knockout studies in mice suggested that this protein may negatively regulate the expression of different cytokines, chemokines, and chemokine receptors, and thus plays an important role in lymphocyte differentiation and migration, as well as in immune responses. [provided by RefSeq, Jul 2008].

PCGF2 Ontologies

Gene Ontology
Process: GO:122; negative regulation of transcription by RNA polymerase II
GO:36353; histone H2A-K119 monoubiquitination
GO:1701; in utero embryonic development
GO:9952; anterior/posterior pattern specification
GO:16573; histone acetylation
GO:48704; embryonic skeletal system morphogenesis
GO:48706; embryonic skeletal system development
GO:70301; cellular response to hydrogen peroxide
GO:2001234; negative regulation of apoptotic signaling pathway
Cellular component: GO:5634; nucleus
GO:5654; nucleoplasm
GO:785; chromatin
GO:31519; PcG protein complex
GO:35102; PRC1 complex
GO:1739; sex chromatin
GO:16604; nuclear body
Function: GO:46872; metal ion binding
GO:3677; DNA binding
GO:5515; protein binding
GO:1990841; promoter-specific chromatin binding
GO:3682; chromatin binding
Show all GO terms

Homologs of PCGF2 in Model Organisms

Mus musculus
Pcgf2
Rattus norvegicus
Pcgf2

External links

OMIM
600346
Ensembl
ENSG00000277258
Entrez Gene
7703
UniGene
713595
1000 Genomes
1000 Genomes
HPRD
GenAtlas
PCGF2
GeneCards
PCGF2