Cell Senescence Entries for PDCD10

Cell Types
Coronary artery endothelial, Lung fibroblast
Cell Lines
IMR-90, Primary cell
Cancer Cell?
No
Method
Knockout
Type of senescence
Oncogene-induced, Replicative
Senescence Effect
Induces
Primary Reference
Guerrero et al. (2015) The cerebral cavernous malformation 3 gene is necessary for senescence induction. Aging Cell 14(2)274-83 (PubMed)

PDCD10 Gene Information

HGNC symbol
PDCD10 
Aliases
CCM3; TFAR15 
Common name
programmed cell death 10 
Entrez Id
11235
Description
This gene encodes an evolutionarily conserved protein associated with cell apoptosis. The protein interacts with the serine/threonine protein kinase MST4 to modulate the extracellular signal-regulated kinase (ERK) pathway. It also interacts with and is phosphoryated by serine/threonine kinase 25, and is thought to function in a signaling pathway essential for vascular developent. Mutations in this gene are one cause of cerebral cavernous malformations, which are vascular malformations that cause seizures and cerebral hemorrhages. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008].

PDCD10 Ontologies

Gene Ontology
Process: GO:43066; negative regulation of apoptotic process
GO:6915; apoptotic process
GO:10629; negative regulation of gene expression
GO:1525; angiogenesis
GO:8284; positive regulation of cell population proliferation
GO:33138; positive regulation of peptidyl-serine phosphorylation
GO:50821; protein stabilization
GO:71902; positive regulation of protein serine/threonine kinase activity
GO:10628; positive regulation of gene expression
GO:30335; positive regulation of cell migration
GO:32874; positive regulation of stress-activated MAPK cascade
And 15 more GO terms
Cellular component: GO:5737; cytoplasm
GO:16020; membrane
GO:5794; Golgi apparatus
GO:5886; plasma membrane
GO:5829; cytosol
GO:139; Golgi membrane
GO:70062; extracellular exosome
GO:90443; FAR/SIN/STRIPAK complex
Function: GO:42803; protein homodimerization activity
GO:5515; protein binding
GO:19901; protein kinase binding
GO:47485; protein N-terminus binding
Show all GO terms

Homologs of PDCD10 in Model Organisms

Caenorhabditis elegans
C14A4.11
Danio rerio
pdcd10a
Drosophila melanogaster
CG5073
Mus musculus
Pdcd10
Rattus norvegicus
Pdcd10

External links

OMIM
609118
Ensembl
ENSG00000114209
Entrez Gene
11235
UniGene
478150
1000 Genomes
1000 Genomes
HPRD
GenAtlas
PDCD10
GeneCards
PDCD10