Cell Senescence Entries for PDZD2
- Cell Types
- Breast cancer, Liver cancer, Prostate cancer
- Cell Lines
- DU145
- Cancer Cell?
- Yes
- Method
- Overexpression
- Type of senescence
- Unclear
- Senescence Effect
- Induces
- Primary Reference
- Tam et al. (2008) The autocrine human secreted PDZ domain-containing protein 2 (sPDZD2) induces senescence or quiescence of prostate, breast and liver cancer cells via transcriptional activation of p53. Cancer Lett 271(1)64-80 (PubMed)
PDZD2 Gene Information
- HGNC symbol
- PDZD2
- Aliases
- KIAA0300; PDZK3
- Common name
- PDZ domain containing 2
- Entrez Id
- 23037
- Description
- The protein encoded by this gene contains six PDZ domains and shares sequence similarity with pro-interleukin-16 (pro-IL-16). Like pro-IL-16, the encoded protein localizes to the endoplasmic reticulum and is thought to be cleaved by a caspase to produce a secreted peptide containing two PDZ domains. In addition, this gene is upregulated in primary prostate tumors and may be involved in the early stages of prostate tumorigenesis. [provided by RefSeq, Dec 2015].
PDZD2 Ontologies
- Gene Ontology
-
Process: GO:7155; cell adhesion
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:43231; intracellular membrane-bounded organelle
GO:5783; endoplasmic reticulum
GO:5829; cytosol
GO:5886; plasma membrane
GO:5576; extracellular region
GO:34451; centriolar satellite
GO:5911; cell-cell junction
Show all GO termsFunction: GO:5515; protein binding
Homologs of PDZD2 in Model Organisms
External links
- OMIM
- 610697
- Ensembl
- ENSG00000133401
- Entrez Gene
- 23037
- UniGene
- 481819
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- PDZD2
- GeneCards
- PDZD2