Cell Senescence Entries for PGR

Cell Types
Ovarian cancer
Cell Lines
PEO4
Cancer Cell?
Yes
Method
Overexpression
Type of senescence
Stress-induced
Senescence Effect
Induces
Primary Reference
Diep et al. (2013) Progesterone receptors induce FOXO1-dependent senescence in ovarian cancer cells. Cell Cycle 12(9)1433-49 (PubMed)

PGR Gene Information

HGNC symbol
PGR 
Aliases
NR3C3; PR 
Common name
progesterone receptor 
Entrez Id
5241
Description
This gene encodes a member of the steroid receptor superfamily. The encoded protein mediates the physiological effects of progesterone, which plays a central role in reproductive events associated with the establishment and maintenance of pregnancy. This gene uses two distinct promotors and translation start sites in the first exon to produce several transcript variants, both protein coding and non-protein coding. Two of the isoforms (A and B) are identical except for an additional 165 amino acids found in the N-terminus of isoform B and mediate their own response genes and physiologic effects with little overlap. [provided by RefSeq, Sep 2015].

PGR Ontologies

Gene Ontology
Process: GO:6355; regulation of transcription, DNA-templated
GO:10629; negative regulation of gene expression
GO:6357; regulation of transcription by RNA polymerase II
GO:45944; positive regulation of transcription by RNA polymerase II
GO:43401; steroid hormone mediated signaling pathway
GO:7165; signal transduction
GO:7267; cell-cell signaling
GO:10628; positive regulation of gene expression
GO:30518; intracellular steroid hormone receptor signaling pathway
GO:1542; ovulation from ovarian follicle
GO:2070; epithelial cell maturation
And 7 more GO terms
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:16020; membrane
GO:5739; mitochondrion
GO:5741; mitochondrial outer membrane
GO:785; chromatin
GO:5654; nucleoplasm
GO:5829; cytosol
Function: GO:8270; zinc ion binding
GO:46872; metal ion binding
GO:3677; DNA binding
GO:3700; DNA-binding transcription factor activity
GO:43565; sequence-specific DNA binding
GO:5515; protein binding
GO:8289; lipid binding
GO:5102; signaling receptor binding
GO:19899; enzyme binding
GO:42802; identical protein binding
GO:978; RNA polymerase II cis-regulatory region sequence-specific DNA binding
And 8 more GO terms
Show all GO terms

Homologs of PGR in Model Organisms

Mus musculus
Pgr
Rattus norvegicus
Pgr

External links

OMIM
607311
Ensembl
ENSG00000082175
Entrez Gene
5241
UniGene
742403
1000 Genomes
1000 Genomes
HPRD
GenAtlas
PGR
GeneCards
PGR