Cell Senescence Entries for PIK3C2A

Cell Types
Embryonic kidney, Retinal pigment epithelial
Cell Lines
HEK293T, HTERT-RPE1
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Unclear
Senescence Effect
Unclear
Primary Reference
Lahtela et al. (2013) A high-content cellular senescence screen identifies candidate tumor suppressors, including EPHA3. Cell Cycle 12(4)625-34 (PubMed)

PIK3C2A Gene Information

HGNC symbol
PIK3C2A 
Aliases
PI3K-C2alpha 
Common name
phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha 
Entrez Id
5286
Description
The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is not sensitive to nanomolar levels of the inhibitor wortmanin. This protein was shown to be able to be activated by insulin and may be involved in integrin-dependent signaling. [provided by RefSeq, Jul 2008].

PIK3C2A Ontologies

Gene Ontology
Process: GO:16310; phosphorylation
GO:6629; lipid metabolic process
GO:6887; exocytosis
GO:46854; phosphatidylinositol phosphate biosynthetic process
GO:6661; phosphatidylinositol biosynthetic process
GO:48015; phosphatidylinositol-mediated signaling
GO:6897; endocytosis
GO:16477; cell migration
GO:48268; clathrin coat assembly
GO:14065; phosphatidylinositol 3-kinase signaling
GO:36092; phosphatidylinositol-3-phosphate biosynthetic process
And 8 more GO terms
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:16020; membrane
GO:5794; Golgi apparatus
GO:31410; cytoplasmic vesicle
GO:43231; intracellular membrane-bounded organelle
GO:5654; nucleoplasm
GO:5829; cytosol
GO:5886; plasma membrane
GO:5802; trans-Golgi network
GO:31982; vesicle
And 4 more GO terms
Function: GO:166; nucleotide binding
GO:5524; ATP binding
GO:16301; kinase activity
GO:16740; transferase activity
GO:35091; phosphatidylinositol binding
GO:46934; phosphatidylinositol-4,5-bisphosphate 3-kinase activity
GO:52812; phosphatidylinositol-3,4-bisphosphate 5-kinase activity
GO:35004; phosphatidylinositol 3-kinase activity
GO:35005; 1-phosphatidylinositol-4-phosphate 3-kinase activity
GO:16303; 1-phosphatidylinositol-3-kinase activity
GO:52742; phosphatidylinositol kinase activity
And 2 more GO terms
Show all GO terms

Homologs of PIK3C2A in Model Organisms

Danio rerio
pik3c2a
Mus musculus
Pik3c2a
Rattus norvegicus
Pik3c2a

External links

OMIM
603601
Ensembl
ENSG00000011405
Entrez Gene
5286
UniGene
736397
1000 Genomes
1000 Genomes
HPRD
GenAtlas
PIK3C2A
GeneCards
PIK3C2A