Cell Senescence Entries for PIK3R5

Cell Types
Embryonic kidney, Lung fibroblast
Cell Lines
HEK293T, IMR-90, MRC-5
Cancer Cell?
No
Method
Overexpression
Type of senescence
Unclear
Senescence Effect
Induces
Primary Reference
Ferrand et al. (2016) Screening of a kinase library reveals novel pro-senescence kinases and their common NF-κB-dependent transcriptional program. Aging (Albany NY) 7(11)986-1003 (PubMed)

PIK3R5 Gene Information

HGNC symbol
PIK3R5 
Aliases
p101; P101-PI3K 
Common name
phosphoinositide-3-kinase regulatory subunit 5 
Entrez Id
23533
Description
Phosphatidylinositol 3-kinases (PI3Ks) phosphorylate the inositol ring of phosphatidylinositol at the 3-prime position, and play important roles in cell growth, proliferation, differentiation, motility, survival and intracellular trafficking. The PI3Ks are divided into three classes: I, II and III, and only the class I PI3Ks are involved in oncogenesis. This gene encodes the 101 kD regulatory subunit of the class I PI3K gamma complex, which is a dimeric enzyme, consisting of a 110 kD catalytic subunit gamma and a regulatory subunit of either 55, 87 or 101 kD. This protein recruits the catalytic subunit from the cytosol to the plasma membrane through high-affinity interaction with G-beta-gamma proteins. Multiple alternatively spliced transcript variants encoding two distinct isoforms have been found. [provided by RefSeq, Oct 2011].

PIK3R5 Ontologies

Gene Ontology
Process: GO:43551; regulation of phosphatidylinositol 3-kinase activity
GO:16310; phosphorylation
GO:7186; G protein-coupled receptor signaling pathway
GO:51897; positive regulation of protein kinase B signaling
GO:14065; phosphatidylinositol 3-kinase signaling
GO:43406; positive regulation of MAP kinase activity
GO:6955; immune response
Cellular component: GO:5944; phosphatidylinositol 3-kinase complex, class IB
GO:5634; nucleus
GO:5737; cytoplasm
GO:16020; membrane
GO:5829; cytosol
GO:5886; plasma membrane
GO:34451; centriolar satellite
GO:5942; phosphatidylinositol 3-kinase complex
GO:5943; phosphatidylinositol 3-kinase complex, class IA
Function: GO:46935; 1-phosphatidylinositol-3-kinase regulator activity
GO:16301; kinase activity
GO:31683; G-protein beta/gamma-subunit complex binding
Show all GO terms

Homologs of PIK3R5 in Model Organisms

Danio rerio
pik3r5
Mus musculus
Pik3r5
Rattus norvegicus
Pik3r5

External links

OMIM
611317
Ensembl
ENSG00000141506
Entrez Gene
23533
UniGene
738684
1000 Genomes
1000 Genomes
HPRD
GenAtlas
PIK3R5
GeneCards
PIK3R5