Cell Senescence Entries for PIR

Cell Types
Melanoma
Cell Lines
IGR37, WM266-4
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Oncogene-induced, Stress-induced
Senescence Effect
Inhibits
Primary Reference
Licciulli et al. (2011) Pirin inhibits cellular senescence in melanocytic cells. Am J Pathol 178(5)2397-406 (PubMed)

PIR Gene Information

HGNC symbol
PIR 
Aliases
 
Common name
pirin 
Entrez Id
8544
Description
This gene encodes a member of the cupin superfamily. The encoded protein is an Fe(II)-containing nuclear protein expressed in all tissues of the body and concentrated within dot-like subnuclear structures. Interactions with nuclear factor I/CCAAT box transcription factor as well as B cell lymphoma 3-encoded oncoprotein suggest the encoded protein may act as a transcriptional cofactor and be involved in the regulation of DNA transcription and replication. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008].

PIR Ontologies

Gene Ontology
Process: GO:30099; myeloid cell differentiation
GO:6355; regulation of transcription, DNA-templated
GO:6366; transcription by RNA polymerase II
GO:30224; monocyte differentiation
GO:7586; digestion
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:5829; cytosol
GO:5654; nucleoplasm
Function: GO:46872; metal ion binding
GO:16491; oxidoreductase activity
GO:51213; dioxygenase activity
GO:5515; protein binding
GO:3712; transcription coregulator activity
GO:8127; quercetin 2,3-dioxygenase activity
Show all GO terms

Homologs of PIR in Model Organisms

Danio rerio
pir
Mus musculus
Pir
Rattus norvegicus
Pir

External links

OMIM
300931
Ensembl
ENSG00000087842
Entrez Gene
8544
UniGene
732521
1000 Genomes
1000 Genomes
HPRD
GenAtlas
PIR
GeneCards
PIR