Cell Senescence Entries for PITX1

Cell Types
Melanoma
Cell Lines
A2058
Cancer Cell?
Yes
Method
Mutation, Overexpression
Type of senescence
Replicative
Senescence Effect
Induces
Primary Reference
Ohira et al. (2020) PITX1 protein interacts with ZCCHC10 to regulate hTERT mRNA transcription. PLoS One 14(8)e0217605 (PubMed)

PITX1 Gene Information

HGNC symbol
PITX1 
Aliases
BFT; POTX; PTX1 
Common name
paired like homeodomain 1 
Entrez Id
5307
Description
This gene encodes a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. Members of this family are involved in organ development and left-right asymmetry. This protein acts as a transcriptional regulator involved in basal and hormone-regulated activity of prolactin. [provided by RefSeq, Jul 2008].

PITX1 Ontologies

Gene Ontology
Process: GO:6355; regulation of transcription, DNA-templated
GO:6357; regulation of transcription by RNA polymerase II
GO:9653; anatomical structure morphogenesis
GO:1501; skeletal system development
GO:14707; branchiomeric skeletal muscle development
GO:21983; pituitary gland development
GO:35116; embryonic hindlimb morphogenesis
GO:35137; hindlimb morphogenesis
GO:45892; negative regulation of transcription, DNA-templated
GO:45944; positive regulation of transcription by RNA polymerase II
GO:48625; myoblast fate commitment
And 2 more GO terms
Cellular component: GO:5634; nucleus
GO:785; chromatin
GO:5667; transcription regulator complex
GO:5737; cytoplasm
Function: GO:3677; DNA binding
GO:3700; DNA-binding transcription factor activity
GO:981; DNA-binding transcription factor activity, RNA polymerase II-specific
GO:5515; protein binding
GO:978; RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:1990837; sequence-specific double-stranded DNA binding
GO:61629; RNA polymerase II-specific DNA-binding transcription factor binding
GO:1228; DNA-binding transcription activator activity, RNA polymerase II-specific
Show all GO terms

Homologs of PITX1 in Model Organisms

Danio rerio
pitx1
Mus musculus
Pitx1
Rattus norvegicus
Pitx1

External links

OMIM
602149
Ensembl
ENSG00000069011
Entrez Gene
5307
UniGene
84136
1000 Genomes
1000 Genomes
HPRD
GenAtlas
PITX1
GeneCards
PITX1