Cell Senescence Entries for PLA2R1

Cell Types
Lung fibroblast
Cell Lines
IMR-90, WI-38
Cancer Cell?
No
Method
Knockout, Overexpression
Type of senescence
Replicative, Stress-induced
Senescence Effect
Induces
Primary Reference
Augert et al. (2009) The M-type receptor PLA2R regulates senescence through the p53 pathway. EMBO Rep 10(3)271-7 (PubMed)

PLA2R1 Gene Information

HGNC symbol
PLA2R1 
Aliases
CLEC13C; PLA2-R; PLA2G1R; PLA2IR 
Common name
phospholipase A2 receptor 1 
Entrez Id
22925
Description
This gene represents a phospholipase A2 receptor. The encoded protein likely exists as both a transmembrane form and a soluble form. The transmembrane receptor may play a role in clearance of phospholipase A2, thereby inhibiting its action. Polymorphisms at this locus have been associated with susceptibility to idiopathic membranous nephropathy. Alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Sep 2010].

PLA2R1 Ontologies

Gene Ontology
Process: GO:6897; endocytosis
GO:72593; reactive oxygen species metabolic process
GO:1819; positive regulation of cytokine production
GO:90403; oxidative stress-induced premature senescence
GO:43517; positive regulation of DNA damage response, signal transduction by p53 class mediator
GO:6898; receptor-mediated endocytosis
GO:1904635; positive regulation of glomerular visceral epithelial cell apoptotic process
GO:90399; replicative senescence
GO:1900138; negative regulation of phospholipase A2 activity
GO:90238; positive regulation of arachidonic acid secretion
GO:1900139; negative regulation of arachidonic acid secretion
And 1 more GO terms
Cellular component: GO:16020; membrane
GO:16021; integral component of membrane
GO:5886; plasma membrane
GO:5576; extracellular region
GO:9986; cell surface
GO:5887; integral component of plasma membrane
GO:43235; receptor complex
Function: GO:30246; carbohydrate binding
GO:38023; signaling receptor activity
GO:43274; phospholipase binding
Show all GO terms

Homologs of PLA2R1 in Model Organisms

Danio rerio
uncharacterized_E7FB
Mus musculus
Pla2r1
Rattus norvegicus
Pla2r1

External links

OMIM
604939
Ensembl
ENSG00000153246
Entrez Gene
22925
UniGene
410477
1000 Genomes
1000 Genomes
HPRD
GenAtlas
PLA2R1
GeneCards
PLA2R1