Cell Senescence Entries for PML

Cell Types
Lung fibroblast
Cell Lines
WI-38
Cancer Cell?
No
Method
Overexpression
Type of senescence
Oncogene-induced
Senescence Effect
Induces
Primary Reference
Pearson et al. (2000) PML regulates p53 acetylation and premature senescence induced by oncogenic Ras. Nature 406(6792)207-10 (PubMed)

PML Gene Information

HGNC symbol
PML 
Aliases
MYL; RNF71; TRIM19 
Common name
PML nuclear body scaffold 
Entrez Id
5371
Description
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL). Extensive alternative splicing of this gene results in several variations of the protein's central and C-terminal regions; all variants encode the same N-terminus. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008].

PML Ontologies

Gene Ontology
Process: GO:6915; apoptotic process
GO:45892; negative regulation of transcription, DNA-templated
GO:6355; regulation of transcription, DNA-templated
GO:45893; positive regulation of transcription, DNA-templated
GO:16567; protein ubiquitination
GO:2376; immune system process
GO:45087; innate immune response
GO:51607; defense response to virus
GO:48511; rhythmic process
GO:16925; protein sumoylation
GO:32922; circadian regulation of gene expression
And 59 more GO terms
Cellular component: GO:781; chromosome, telomeric region
GO:5634; nucleus
GO:5737; cytoplasm
GO:16020; membrane
GO:5783; endoplasmic reticulum
GO:5789; endoplasmic reticulum membrane
GO:5768; endosome
GO:5829; cytosol
GO:5730; nucleolus
GO:5654; nucleoplasm
GO:16605; PML body
And 6 more GO terms
Function: GO:5515; protein binding
GO:8270; zinc ion binding
GO:46872; metal ion binding
GO:16740; transferase activity
GO:3677; DNA binding
GO:31625; ubiquitin protein ligase binding
GO:3713; transcription coactivator activity
GO:4842; ubiquitin-protein transferase activity
GO:42803; protein homodimerization activity
GO:19789; SUMO transferase activity
GO:32183; SUMO binding
And 5 more GO terms
Show all GO terms

Homologs of PML in Model Organisms

Mus musculus
Pml
Rattus norvegicus
Pml

In other databases

GenAge human genes
  • This gene is present as PML

External links

OMIM
102578
Ensembl
ENSG00000140464
Entrez Gene
5371
UniGene
654583
1000 Genomes
1000 Genomes
HPRD
GenAtlas
PML
GeneCards
PML