Cell Senescence Entries for PMVK

Cell Types
Embryonic kidney, Lung fibroblast
Cell Lines
HEK293T, IMR-90, MRC-5
Cancer Cell?
No
Method
Overexpression
Type of senescence
Unclear
Senescence Effect
Induces
Primary Reference
Ferrand et al. (2016) Screening of a kinase library reveals novel pro-senescence kinases and their common NF-κB-dependent transcriptional program. Aging (Albany NY) 7(11)986-1003 (PubMed)

PMVK Gene Information

HGNC symbol
PMVK 
Aliases
HUMPMKI; PMK; PMKA 
Common name
phosphomevalonate kinase 
Entrez Id
10654
Description
This gene encodes a peroxisomal enzyme that is a member of the galactokinase, homoserine kinase, mevalonate kinase, and phosphomevalonate kinase (GHMP) family of ATP-dependent enzymes. The encoded protein catalyzes the conversion of mevalonate 5-phosphate to mevalonate 5-diphosphate, which is the fifth step in the mevalonate pathway of isoprenoid biosynthesis. Mutations in this gene are linked to certain types of porokeratosis including disseminated superficial porokeratosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2017].

PMVK Ontologies

Gene Ontology
Process: GO:16310; phosphorylation
GO:6629; lipid metabolic process
GO:6694; steroid biosynthetic process
GO:6695; cholesterol biosynthetic process
GO:8202; steroid metabolic process
GO:8203; cholesterol metabolic process
GO:16126; sterol biosynthetic process
GO:19287; isopentenyl diphosphate biosynthetic process, mevalonate pathway
GO:70723; response to cholesterol
Cellular component: GO:5737; cytoplasm
GO:16020; membrane
GO:5829; cytosol
GO:5777; peroxisome
GO:70062; extracellular exosome
Function: GO:166; nucleotide binding
GO:5524; ATP binding
GO:16301; kinase activity
GO:16740; transferase activity
GO:5515; protein binding
GO:4631; phosphomevalonate kinase activity
Show all GO terms

Homologs of PMVK in Model Organisms

Caenorhabditis elegans
CELE_F32D8.13
Danio rerio
pmvk
Drosophila melanogaster
CG10268
Mus musculus
Pmvk
Rattus norvegicus
Pmvk

External links

OMIM
607622
Ensembl
ENSG00000163344
Entrez Gene
10654
UniGene
30954
1000 Genomes
1000 Genomes
HPRD
GenAtlas
PMVK
GeneCards
PMVK