Cell Senescence Entries for PNPT1

Cell Types
Melanoma
Cell Lines
FO-1, HO-1, MeWo
Cancer Cell?
Yes
Method
Overexpression
Type of senescence
Replicative
Senescence Effect
Induces
Primary Reference
Sarkar et al. (2003) Down-regulation of Myc as a potential target for growth arrest induced by human polynucleotide phosphorylase (hPNPaseold-35) in human melanoma cells. J Biol Chem 278(27)24542-51 (PubMed)

PNPT1 Gene Information

HGNC symbol
PNPT1 
Aliases
DFNB70; old-35; OLD35; PNPase 
Common name
polyribonucleotide nucleotidyltransferase 1 
Entrez Id
87178
Description
The protein encoded by this gene belongs to the evolutionary conserved polynucleotide phosphorylase family comprised of phosphate dependent 3'-to-5' exoribonucleases implicated in RNA processing and degradation. This enzyme is predominantly localized in the mitochondrial intermembrane space and is involved in import of RNA to mitochondria. Mutations in this gene have been associated with combined oxidative phosphorylation deficiency-13 and autosomal recessive nonsyndromic deafness-70. Related pseudogenes are found on chromosomes 3 and 7. [provided by RefSeq, Dec 2012].

PNPT1 Ontologies

Gene Ontology
Process: GO:6396; RNA processing
GO:6397; mRNA processing
GO:90305; nucleic acid phosphodiester bond hydrolysis
GO:61014; positive regulation of mRNA catabolic process
GO:90503; RNA phosphodiester bond hydrolysis, exonucleolytic
GO:51726; regulation of cell cycle
GO:6402; mRNA catabolic process
GO:51260; protein homooligomerization
GO:35458; cellular response to interferon-beta
GO:2000627; positive regulation of miRNA catabolic process
GO:6401; RNA catabolic process
And 21 more GO terms
Cellular component: GO:5737; cytoplasm
GO:16020; membrane
GO:5829; cytosol
GO:5739; mitochondrion
GO:5759; mitochondrial matrix
GO:5758; mitochondrial intermembrane space
GO:45025; mitochondrial degradosome
GO:5634; nucleus
GO:5789; endoplasmic reticulum membrane
GO:42788; polysomal ribosome
GO:1902494; catalytic complex
And 1 more GO terms
Function: GO:3676; nucleic acid binding
GO:3723; RNA binding
GO:16740; transferase activity
GO:16787; hydrolase activity
GO:4518; nuclease activity
GO:5515; protein binding
GO:4527; exonuclease activity
GO:16779; nucleotidyltransferase activity
GO:175; 3'-5'-exoribonuclease activity
GO:4654; polyribonucleotide nucleotidyltransferase activity
GO:34046; poly(G) binding
And 3 more GO terms
Show all GO terms

Homologs of PNPT1 in Model Organisms

Caenorhabditis elegans
BE0003N10.1
Drosophila melanogaster
CG11337-RD
Mus musculus
Pnpt1
Rattus norvegicus
Pnpt1

External links

OMIM
610316
Ensembl
ENSG00000138035
Entrez Gene
87178
UniGene
388733
1000 Genomes
1000 Genomes
HPRD
GenAtlas
PNPT1
GeneCards
PNPT1