Cell Senescence Entries for PON1

Cell Types
Dermal microvascular endothelial
Cell Lines
HDMEC
Cancer Cell?
No
Method
Knockdown
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Lee et al. (2013) Knockdown of paraoxonase 1 expression influences the ageing of human dermal microvascular endothelial cells. Exp Dermatol 21(9)682-7 (PubMed)

PON1 Gene Information

HGNC symbol
PON1 
Aliases
ESA; PON 
Common name
paraoxonase 1 
Entrez Id
5444
Description
This gene encodes a member of the paraoxonase family of enzymes and exhibits lactonase and ester hydrolase activity. Following synthesis in the kidney and liver, the enzyme is secreted into the circulation, where it binds to high density lipoprotein (HDL) particles and hydrolyzes thiolactones and xenobiotics, including paraoxon, a metabolite of the insecticide parathion. Polymorphisms in this gene may be associated with coronary artery disease and diabetic retinopathy. The gene is found in a cluster of three related paraoxonase genes on chromosome 7. [provided by RefSeq, Aug 2017].

PON1 Ontologies

Gene Ontology
Process: GO:16311; dephosphorylation
GO:51099; positive regulation of binding
GO:10875; positive regulation of cholesterol efflux
GO:46470; phosphatidylcholine metabolic process
GO:32411; positive regulation of transporter activity
GO:6629; lipid metabolic process
GO:8203; cholesterol metabolic process
GO:9636; response to toxic substance
GO:19439; aromatic compound catabolic process
GO:31667; response to nutrient levels
GO:46395; carboxylic acid catabolic process
And 4 more GO terms
Cellular component: GO:5615; extracellular space
GO:5576; extracellular region
GO:34364; high-density lipoprotein particle
GO:70062; extracellular exosome
GO:72562; blood microparticle
GO:34366; spherical high-density lipoprotein particle
GO:43231; intracellular membrane-bounded organelle
Function: GO:46872; metal ion binding
GO:16787; hydrolase activity
GO:5509; calcium ion binding
GO:4064; arylesterase activity
GO:102007; acyl-L-homoserine-lactone lactonohydrolase activity
GO:42803; protein homodimerization activity
GO:5543; phospholipid binding
GO:4063; aryldialkylphosphatase activity
Show all GO terms

Homologs of PON1 in Model Organisms

Mus musculus
Pon1
Rattus norvegicus
Pon1

In other databases

GenAge human genes
  • This gene is present as PON1
LongevityMap
  • This gene is present as PON1

External links

OMIM
168820
Ensembl
ENSG00000005421
Entrez Gene
5444
UniGene
370995
1000 Genomes
1000 Genomes
HPRD
GenAtlas
PON1
GeneCards
PON1