Cell Senescence Entries for PPARG

Cell Types
Lung fibroblast
Cell Lines
2BS, WI-38
Cancer Cell?
No
Method
Knockdown
Type of senescence
Replicative
Senescence Effect
Induces
Primary Reference
Gan et al. (2008) PPAR{gamma} accelerates cellular senescence by inducing p16INK4{alpha} expression in human diploid fibroblasts. J Cell Sci 121(Pt 13)2235-45 (PubMed)

PPARG Gene Information

HGNC symbol
PPARG 
Aliases
NR1C3; PPARG1; PPARG2; PPARgamma 
Common name
peroxisome proliferator activated receptor gamma 
Entrez Id
5468
Description
This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear receptors. PPARs form heterodimers with retinoid X receptors (RXRs) and these heterodimers regulate transcription of various genes. Three subtypes of PPARs are known: PPAR-alpha, PPAR-delta, and PPAR-gamma. The protein encoded by this gene is PPAR-gamma and is a regulator of adipocyte differentiation. Additionally, PPAR-gamma has been implicated in the pathology of numerous diseases including obesity, diabetes, atherosclerosis and cancer. Alternatively spliced transcript variants that encode different isoforms have been described. [provided by RefSeq, Jul 2008].

PPARG Ontologies

Gene Ontology
Process: GO:6355; regulation of transcription, DNA-templated
GO:30522; intracellular receptor signaling pathway
GO:48511; rhythmic process
GO:7154; cell communication
GO:51716; cellular response to stimulus
GO:6357; regulation of transcription by RNA polymerase II
GO:2674; negative regulation of acute inflammatory response
GO:7507; heart development
GO:8285; negative regulation of cell population proliferation
GO:9409; response to cold
GO:9410; response to xenobiotic stimulus
And 102 more GO terms
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:43231; intracellular membrane-bounded organelle
GO:5654; nucleoplasm
GO:5829; cytosol
GO:48471; perinuclear region of cytoplasm
GO:43235; receptor complex
GO:785; chromatin
GO:90575; RNA polymerase II transcription regulator complex
Function: GO:8270; zinc ion binding
GO:46872; metal ion binding
GO:3677; DNA binding
GO:3700; DNA-binding transcription factor activity
GO:43565; sequence-specific DNA binding
GO:4879; nuclear receptor activity
GO:976; transcription cis-regulatory region binding
GO:19903; protein phosphatase binding
GO:30331; estrogen receptor binding
GO:5515; protein binding
GO:19899; enzyme binding
And 21 more GO terms
Show all GO terms

Homologs of PPARG in Model Organisms

Danio rerio
pparg
Mus musculus
Pparg
Rattus norvegicus
Pparg

In other databases

GenAge model organism genes
  • A homolog of this gene for Mus musculus is present as Pparg
GenAge human genes
  • This gene is present as PPARG
LongevityMap
  • This gene is present as PPARG

External links

OMIM
601487
Ensembl
ENSG00000132170
Entrez Gene
5468
UniGene
655798
1000 Genomes
1000 Genomes
HPRD
GenAtlas
PPARG
GeneCards
PPARG