Cell Senescence Entries for PPARG

Cell Types
Lung fibroblast
Cell Lines
2BS, WI-38
Cancer Cell?
No
Method
Knockdown
Type of senescence
Replicative
Senescence Effect
Induces
Primary Reference
Gan et al. (2008) PPAR{gamma} accelerates cellular senescence by inducing p16INK4{alpha} expression in human diploid fibroblasts. J Cell Sci 121(Pt 13)2235-45 (PubMed)

PPARG Gene Information

HGNC symbol
PPARG 
Aliases
NR1C3; PPARG1; PPARG2; PPARgamma 
Common name
peroxisome proliferator activated receptor gamma 
Entrez Id
5468
Description
This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear receptors. PPARs form heterodimers with retinoid X receptors (RXRs) and these heterodimers regulate transcription of various genes. Three subtypes of PPARs are known: PPAR-alpha, PPAR-delta, and PPAR-gamma. The protein encoded by this gene is PPAR-gamma and is a regulator of adipocyte differentiation. Additionally, PPAR-gamma has been implicated in the pathology of numerous diseases including obesity, diabetes, atherosclerosis and cancer. Alternatively spliced transcript variants that encode different isoforms have been described. [provided by RefSeq, Jul 2008].

PPARG Ontologies

Gene Ontology
Process: GO:6355; regulation of transcription, DNA-templated
GO:30522; intracellular receptor signaling pathway
GO:48511; rhythmic process
GO:7154; cell communication
GO:51716; cellular response to stimulus
GO:6357; regulation of transcription by RNA polymerase II
GO:2674; negative regulation of acute inflammatory response
GO:7507; heart development
GO:8285; negative regulation of cell population proliferation
GO:9409; response to cold
GO:9410; response to xenobiotic stimulus
GO:9612; response to mechanical stimulus
GO:10033; response to organic substance
GO:10629; negative regulation of gene expression
GO:10888; negative regulation of lipid storage
GO:14070; response to organic cyclic compound
GO:19216; regulation of lipid metabolic process
GO:19395; fatty acid oxidation
GO:30308; negative regulation of cell growth
GO:31000; response to caffeine
GO:31100; animal organ regeneration
GO:32966; negative regulation of collagen biosynthetic process
GO:33189; response to vitamin A
GO:33993; response to lipid
GO:35902; response to immobilization stress
GO:42594; response to starvation
GO:43065; positive regulation of apoptotic process
GO:43627; response to estrogen
GO:45598; regulation of fat cell differentiation
GO:45600; positive regulation of fat cell differentiation
GO:45944; positive regulation of transcription by RNA polymerase II
GO:46321; positive regulation of fatty acid oxidation
GO:48662; negative regulation of smooth muscle cell proliferation
GO:48714; positive regulation of oligodendrocyte differentiation
GO:51974; negative regulation of telomerase activity
GO:60100; positive regulation of phagocytosis, engulfment
GO:70165; positive regulation of adiponectin secretion
GO:71300; cellular response to retinoic acid
GO:71306; cellular response to vitamin E
GO:71379; cellular response to prostaglandin stimulus
GO:71380; cellular response to prostaglandin E stimulus
GO:71455; cellular response to hyperoxia
GO:71456; cellular response to hypoxia
GO:1901558; response to metformin
GO:1903243; negative regulation of cardiac muscle hypertrophy in response to stress
GO:1904597; negative regulation of connective tissue replacement involved in inflammatory response wound healing
GO:2000230; negative regulation of pancreatic stellate cell proliferation
GO:10628; positive regulation of gene expression
GO:60965; negative regulation of gene silencing by miRNA
GO:122; negative regulation of transcription by RNA polymerase II
GO:7186; G protein-coupled receptor signaling pathway
GO:30154; cell differentiation
GO:6631; fatty acid metabolic process
GO:45087; innate immune response
GO:45893; positive regulation of transcription, DNA-templated
GO:30509; BMP signaling pathway
GO:42789; mRNA transcription by RNA polymerase II
GO:45892; negative regulation of transcription, DNA-templated
GO:32869; cellular response to insulin stimulus
GO:51091; positive regulation of DNA-binding transcription factor activity
GO:9755; hormone-mediated signaling pathway
GO:6629; lipid metabolic process
GO:48469; cell maturation
GO:1902894; negative regulation of pri-miRNA transcription by RNA polymerase II
GO:1905461; positive regulation of vascular associated smooth muscle cell apoptotic process
GO:42752; regulation of circadian rhythm
GO:1904893; negative regulation of receptor signaling pathway via STAT
GO:1902895; positive regulation of pri-miRNA transcription by RNA polymerase II
GO:16525; negative regulation of angiogenesis
GO:50872; white fat cell differentiation
GO:30512; negative regulation of transforming growth factor beta receptor signaling pathway
GO:60394; negative regulation of pathway-restricted SMAD protein phosphorylation
GO:7584; response to nutrient
GO:45668; negative regulation of osteoblast differentiation
GO:7165; signal transduction
GO:6919; activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:8217; regulation of blood pressure
GO:60392; negative regulation of SMAD protein signal transduction
GO:42593; glucose homeostasis
GO:10862; positive regulation of pathway-restricted SMAD protein phosphorylation
GO:10745; negative regulation of macrophage derived foam cell differentiation
GO:10887; negative regulation of cholesterol storage
GO:71404; cellular response to low-density lipoprotein particle stimulus
GO:2000272; negative regulation of signaling receptor activity
GO:43537; negative regulation of blood vessel endothelial cell migration
GO:43407; negative regulation of MAP kinase activity
GO:10875; positive regulation of cholesterol efflux
GO:1904706; negative regulation of vascular associated smooth muscle cell proliferation
GO:42953; lipoprotein transport
GO:55088; lipid homeostasis
GO:1905599; positive regulation of low-density lipoprotein receptor activity
GO:48384; retinoic acid receptor signaling pathway
GO:60391; positive regulation of SMAD protein signal transduction
GO:1905563; negative regulation of vascular endothelial cell proliferation
GO:30855; epithelial cell differentiation
GO:45165; cell fate commitment
GO:50728; negative regulation of inflammatory response
GO:15909; long-chain fatty acid transport
GO:30514; negative regulation of BMP signaling pathway
GO:1890; placenta development
GO:10742; macrophage derived foam cell differentiation
GO:10891; negative regulation of sequestering of triglyceride
GO:30224; monocyte differentiation
GO:35357; peroxisome proliferator activated receptor signaling pathway
GO:43388; positive regulation of DNA binding
GO:45923; positive regulation of fatty acid metabolic process
GO:60336; negative regulation of interferon-gamma-mediated signaling pathway
GO:60694; regulation of cholesterol transporter activity
GO:90258; negative regulation of mitochondrial fission
GO:1903845; negative regulation of cellular response to transforming growth factor beta stimulus
GO:1900076; regulation of cellular response to insulin stimulus
GO:1904179; positive regulation of adipose tissue development
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:43231; intracellular membrane-bounded organelle
GO:5654; nucleoplasm
GO:5829; cytosol
GO:48471; perinuclear region of cytoplasm
GO:43235; receptor complex
GO:785; chromatin
GO:90575; RNA polymerase II transcription regulator complex
Function: GO:8270; zinc ion binding
GO:46872; metal ion binding
GO:3677; DNA binding
GO:3700; DNA-binding transcription factor activity
GO:43565; sequence-specific DNA binding
GO:4879; nuclear receptor activity
GO:976; transcription cis-regulatory region binding
GO:19903; protein phosphatase binding
GO:30331; estrogen receptor binding
GO:5515; protein binding
GO:19899; enzyme binding
GO:42802; identical protein binding
GO:1227; DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:978; RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:981; DNA-binding transcription factor activity, RNA polymerase II-specific
GO:140297; DNA-binding transcription factor binding
GO:3682; chromatin binding
GO:70412; R-SMAD binding
GO:70888; E-box binding
GO:1221; transcription coregulator binding
GO:97677; STAT family protein binding
GO:8022; protein C-terminus binding
GO:51393; alpha-actinin binding
GO:3690; double-stranded DNA binding
GO:46965; retinoid X receptor binding
GO:42277; peptide binding
GO:50692; DNA binding domain binding
GO:50693; LBD domain binding
GO:43621; protein self-association
GO:4955; prostaglandin receptor activity
GO:50544; arachidonic acid binding
Hide GO terms

Homologs of PPARG in Model Organisms

Danio rerio
pparg
Mus musculus
Pparg
Rattus norvegicus
Pparg

In other databases

GenAge model organism genes
  • A homolog of this gene for Mus musculus is present as Pparg
GenAge human genes
  • This gene is present as PPARG
LongevityMap
  • This gene is present as PPARG

External links

OMIM
601487
Ensembl
ENSG00000132170
Entrez Gene
5468
UniGene
655798
1000 Genomes
1000 Genomes
HPRD
GenAtlas
PPARG
GeneCards
PPARG