Cell Senescence Entries for PPIB

Cell Types
Glioblastoma
Cell Lines
U251, U87
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Oncogene-induced
Senescence Effect
Inhibits
Primary Reference
Choi et al. (2014) Cyclophilin B supports Myc and mutant p53-dependent survival of glioblastoma multiforme cells. Cancer Res 74(2)484-96 (PubMed)

PPIB Gene Information

HGNC symbol
PPIB 
Aliases
B; CYP-S1; CYPB; OI9; PPIase; SCYLP 
Common name
peptidylprolyl isomerase B 
Entrez Id
5479
Description
The protein encoded by this gene is a cyclosporine-binding protein and is mainly located within the endoplasmic reticulum. It is associated with the secretory pathway and released in biological fluids. This protein can bind to cells derived from T- and B-lymphocytes, and may regulate cyclosporine A-mediated immunosuppression. Variants have been identified in this protein that give rise to recessive forms of osteogenesis imperfecta. [provided by RefSeq, Oct 2009].

PPIB Ontologies

Gene Ontology
Process: GO:413; protein peptidyl-prolyl isomerization
GO:6457; protein folding
GO:60348; bone development
GO:30593; neutrophil chemotaxis
GO:50821; protein stabilization
GO:61077; chaperone-mediated protein folding
GO:44829; positive regulation by host of viral genome replication
GO:44794; positive regulation by host of viral process
GO:40018; positive regulation of multicellular organism growth
Cellular component: GO:5634; nucleus
GO:16020; membrane
GO:5783; endoplasmic reticulum
GO:5654; nucleoplasm
GO:5925; focal adhesion
GO:5788; endoplasmic reticulum lumen
GO:42470; melanosome
GO:48471; perinuclear region of cytoplasm
GO:5737; cytoplasm
GO:43231; intracellular membrane-bounded organelle
GO:70062; extracellular exosome
And 4 more GO terms
Function: GO:16853; isomerase activity
GO:3755; peptidyl-prolyl cis-trans isomerase activity
GO:5515; protein binding
GO:3723; RNA binding
GO:16018; cyclosporin A binding
GO:70063; RNA polymerase binding
GO:51082; unfolded protein binding
GO:5518; collagen binding
Show all GO terms

Homologs of PPIB in Model Organisms

Caenorhabditis elegans
cyn-6
Danio rerio
ppib
Drosophila melanogaster
CG2852
Mus musculus
Ppib
Rattus norvegicus
Ppib

External links

OMIM
123841
Ensembl
ENSG00000166794
Entrez Gene
5479
UniGene
434937
1000 Genomes
1000 Genomes
HPRD
GenAtlas
PPIB
GeneCards
PPIB