Cell Senescence Entries for PROX1

Cell Types
Liver cancer
Cell Lines
Hep G2, Hep3B, Mahlavu, SK-HEP-1
Cancer Cell?
Yes
Method
Overexpression
Type of senescence
Replicative
Senescence Effect
Induces
Primary Reference
Chang et al. (2013) The homeobox transcription factor Prox1 inhibits proliferation of hepatocellular carcinoma cells by inducing p53-dependent senescence-like phenotype. Cancer Biol Ther 14(3)222-9 (PubMed)

PROX1 Gene Information

HGNC symbol
PROX1 
Aliases
 
Common name
prospero homeobox 1 
Entrez Id
5629
Description
The protein encoded by this gene is a member of the homeobox transcription factor family. Members of this family contain a homeobox domain that consists of a 60-amino acid helix-turn-helix structure that binds DNA and RNA. The protein encoded by this gene is conserved across vertebrates and may play an essential role during development. Altered levels of this protein have been reported in cancers of different organs, such as colon, brain, blood, breast, pancreas, liver and esophagus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012].

PROX1 Ontologies

Gene Ontology
Process: GO:6355; regulation of transcription, DNA-templated
GO:45892; negative regulation of transcription, DNA-templated
GO:48511; rhythmic process
GO:6357; regulation of transcription by RNA polymerase II
GO:8284; positive regulation of cell population proliferation
GO:45944; positive regulation of transcription by RNA polymerase II
GO:1938; positive regulation of endothelial cell proliferation
GO:122; negative regulation of transcription by RNA polymerase II
GO:43433; negative regulation of DNA-binding transcription factor activity
GO:10595; positive regulation of endothelial cell migration
GO:42752; regulation of circadian rhythm
And 52 more GO terms
Cellular component: GO:5654; nucleoplasm
GO:5829; cytosol
GO:5737; cytoplasm
GO:5634; nucleus
GO:785; chromatin
Function: GO:5515; protein binding
GO:3677; DNA binding
GO:981; DNA-binding transcription factor activity, RNA polymerase II-specific
GO:978; RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:1990837; sequence-specific double-stranded DNA binding
GO:976; transcription cis-regulatory region binding
GO:3700; DNA-binding transcription factor activity
GO:16922; nuclear receptor binding
GO:1227; DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:43565; sequence-specific DNA binding
GO:50692; DNA binding domain binding
And 2 more GO terms
Show all GO terms

Homologs of PROX1 in Model Organisms

Danio rerio
prox1a
Mus musculus
Prox1
Rattus norvegicus
Prox1

External links

OMIM
601546
Ensembl
ENSG00000117707
Entrez Gene
5629
UniGene
744931
1000 Genomes
1000 Genomes
HPRD
GenAtlas
PROX1
GeneCards
PROX1