Cell Senescence Entries for PSMA2

Cell Types
Melanoma
Cell Lines
A375P
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Oncogene-induced
Senescence Effect
Inhibits
Primary Reference
Cairney et al. (2017) A 'synthetic-sickness' screen for senescence re-engagement targets in mutant cancer backgrounds. PLoS Genet 13(8)e1006942 (PubMed)

PSMA2 Gene Information

HGNC symbol
PSMA2 
Aliases
HC3; MU; PMSA2 
Common name
proteasome 20S subunit alpha 2 
Entrez Id
5683
Description
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. [provided by RefSeq, Jul 2008].

PSMA2 Ontologies

Gene Ontology
Process: GO:6511; ubiquitin-dependent protein catabolic process
GO:51603; proteolysis involved in cellular protein catabolic process
GO:10498; proteasomal protein catabolic process
GO:9615; response to virus
GO:43161; proteasome-mediated ubiquitin-dependent protein catabolic process
GO:16579; protein deubiquitination
GO:43488; regulation of mRNA stability
GO:43687; post-translational protein modification
GO:209; protein polyubiquitination
GO:165; MAPK cascade
GO:2223; stimulatory C-type lectin receptor signaling pathway
And 18 more GO terms
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:502; proteasome complex
GO:932; P-body
GO:5839; proteasome core complex
GO:19773; proteasome core complex, alpha-subunit complex
GO:5576; extracellular region
GO:5654; nucleoplasm
GO:5829; cytosol
GO:70062; extracellular exosome
GO:34774; secretory granule lumen
And 2 more GO terms
Function: GO:5515; protein binding
Show all GO terms

Homologs of PSMA2 in Model Organisms

Caenorhabditis elegans
pas-2
Danio rerio
psma2
Drosophila melanogaster
Pros25
Mus musculus
Psma2
Rattus norvegicus
Psma2
Saccharomyces cerevisiae
PRE8
Schizosaccharomyces pombe
pre8

External links

OMIM
176842
Ensembl
ENSG00000106588
Entrez Gene
5683
UniGene
333786
1000 Genomes
1000 Genomes
HPRD
GenAtlas
PSMA2
GeneCards
PSMA2