Cell Senescence Entries for PSMB1

Cell Types
Colorectal cancer
Cell Lines
HCT116
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Oncogene-induced
Senescence Effect
Inhibits
Primary Reference
Cairney et al. (2017) A 'synthetic-sickness' screen for senescence re-engagement targets in mutant cancer backgrounds. PLoS Genet 13(8)e1006942 (PubMed)

PSMB1 Gene Information

HGNC symbol
PSMB1 
Aliases
HC5; PMSB1 
Common name
proteasome 20S subunit beta 1 
Entrez Id
5689
Description
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. This gene is tightly linked to the TBP (TATA-binding protein) gene in human and in mouse, and is transcribed in the opposite orientation in both species. [provided by RefSeq, Jul 2008].

PSMB1 Ontologies

Gene Ontology
Process: GO:16579; protein deubiquitination
GO:43488; regulation of mRNA stability
GO:43687; post-translational protein modification
GO:209; protein polyubiquitination
GO:165; MAPK cascade
GO:2223; stimulatory C-type lectin receptor signaling pathway
GO:2479; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:6521; regulation of cellular amino acid metabolic process
GO:10972; negative regulation of G2/M transition of mitotic cell cycle
GO:31145; anaphase-promoting complex-dependent catabolic process
GO:31146; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
And 16 more GO terms
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:5654; nucleoplasm
GO:5829; cytosol
GO:502; proteasome complex
GO:5839; proteasome core complex
GO:5576; extracellular region
GO:70062; extracellular exosome
GO:19774; proteasome core complex, beta-subunit complex
GO:34774; secretory granule lumen
GO:1904813; ficolin-1-rich granule lumen
And 1 more GO terms
Function: GO:5515; protein binding
GO:4298; threonine-type endopeptidase activity
GO:8233; peptidase activity
Show all GO terms

Homologs of PSMB1 in Model Organisms

Caenorhabditis elegans
pbs-6
Danio rerio
psmb1
Drosophila melanogaster
Pros26
Mus musculus
Psmb1
Rattus norvegicus
Psmb1
Saccharomyces cerevisiae
PRE7
Schizosaccharomyces pombe
pam1

External links

OMIM
602017
Ensembl
ENSG00000008018
Entrez Gene
5689
UniGene
352768
1000 Genomes
1000 Genomes
HPRD
GenAtlas
PSMB1
GeneCards
PSMB1