Cell Senescence Entries for PTPN6

Cell Types
Nasopharyngeal carcinoma
Cell Lines
CNE-1, CNE-2
Cancer Cell?
Yes
Method
Knockdown, Overexpression
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Sun et al. (2016) Increased SHP-1 expression results in radioresistance, inhibition of cellular senescence, and cell cycle redistribution in nasopharyngeal carcinoma cells. Radiat Oncol 10(2)152 (PubMed)

PTPN6 Gene Information

HGNC symbol
PTPN6 
Aliases
HCP; HCPH; PTP-1C; SHP-1; SHP1 
Common name
protein tyrosine phosphatase non-receptor type 6 
Entrez Id
5777
Description
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. N-terminal part of this PTP contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding domains, and mediate the interaction of this PTP with its substrates. This PTP is expressed primarily in hematopoietic cells, and functions as an important regulator of multiple signaling pathways in hematopoietic cells. This PTP has been shown to interact with, and dephosphorylate a wide spectrum of phospho-proteins involved in hematopoietic cell signaling. Multiple alternatively spliced variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq, Jul 2008].

PTPN6 Ontologies

Gene Ontology
Process: GO:30154; cell differentiation
GO:6470; protein dephosphorylation
GO:16311; dephosphorylation
GO:35335; peptidyl-tyrosine dephosphorylation
GO:6950; response to stress
GO:8285; negative regulation of cell population proliferation
GO:8284; positive regulation of cell population proliferation
GO:7186; G protein-coupled receptor signaling pathway
GO:14068; positive regulation of phosphatidylinositol 3-kinase signaling
GO:19221; cytokine-mediated signaling pathway
GO:70372; regulation of ERK1 and ERK2 cascade
And 27 more GO terms
Cellular component: GO:5737; cytoplasm
GO:5634; nucleus
GO:32991; protein-containing complex
GO:5654; nucleoplasm
GO:5730; nucleolus
GO:5576; extracellular region
GO:5829; cytosol
GO:70062; extracellular exosome
GO:16020; membrane
GO:35580; specific granule lumen
GO:1904724; tertiary granule lumen
And 3 more GO terms
Function: GO:5515; protein binding
GO:16787; hydrolase activity
GO:4721; phosphoprotein phosphatase activity
GO:4725; protein tyrosine phosphatase activity
GO:16791; phosphatase activity
GO:1784; phosphotyrosine residue binding
GO:19901; protein kinase binding
GO:140031; phosphorylation-dependent protein binding
GO:5001; transmembrane receptor protein tyrosine phosphatase activity
GO:17124; SH3 domain binding
GO:42169; SH2 domain binding
And 2 more GO terms
Show all GO terms

Homologs of PTPN6 in Model Organisms

Mus musculus
Ptpn6
Rattus norvegicus
Ptpn6

External links

OMIM
176883
Ensembl
ENSG00000111679
Entrez Gene
5777
UniGene
63489
1000 Genomes
1000 Genomes
HPRD
GenAtlas
PTPN6
GeneCards
PTPN6