Cell Senescence Entries for PURB

Cell Types
Lung cancer
Cell Lines
H358
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Stress-induced
Senescence Effect
Induces
Primary Reference
Mulnix et al. (2013) hnRNP C1/C2 and Pur-beta proteins mediate induction of senescence by oligonucleotides homologous to the telomere overhang. Onco Targets Ther 7(2)23-32 (PubMed)

PURB Gene Information

HGNC symbol
PURB 
Aliases
PURBETA 
Common name
purine rich element binding protein B 
Entrez Id
5814
Description
This gene product is a sequence-specific, single-stranded DNA-binding protein. It binds preferentially to the single strand of the purine-rich element termed PUR, which is present at origins of replication and in gene flanking regions in a variety of eukaryotes from yeasts through humans. Thus, it is implicated in the control of both DNA replication and transcription. Deletion of this gene has been associated with myelodysplastic syndrome and acute myelogenous leukemia. [provided by RefSeq, Jul 2008].

PURB Ontologies

Gene Ontology
Process: GO:30154; cell differentiation
GO:45892; negative regulation of transcription, DNA-templated
GO:6357; regulation of transcription by RNA polymerase II
GO:8283; cell population proliferation
GO:122; negative regulation of transcription by RNA polymerase II
GO:45637; regulation of myeloid cell differentiation
Cellular component: GO:5634; nucleus
GO:5654; nucleoplasm
Function: GO:3723; RNA binding
GO:3677; DNA binding
GO:5515; protein binding
GO:3729; mRNA binding
GO:977; RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:981; DNA-binding transcription factor activity, RNA polymerase II-specific
GO:32422; purine-rich negative regulatory element binding
GO:140297; DNA-binding transcription factor binding
GO:3697; single-stranded DNA binding
GO:1227; DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:3690; double-stranded DNA binding
And 3 more GO terms
Show all GO terms

Homologs of PURB in Model Organisms

Danio rerio
purb
Mus musculus
Purb
Rattus norvegicus
Purb

External links

OMIM
608887
Ensembl
ENSG00000146676
Entrez Gene
5814
UniGene
596321
1000 Genomes
1000 Genomes
HPRD
GenAtlas
PURB
GeneCards
PURB