Cell Senescence Entries for RASSF5
- Cell Types
- Lung cancer
- Cell Lines
- A549
- Cancer Cell?
- Yes
- Method
- Knockdown
- Type of senescence
- Oncogene-induced
- Senescence Effect
- Induces
- Primary Reference
- Donninger et al. (2015) NORE1A is a Ras senescence effector that controls the apoptotic/senescent balance of p53 via HIPK2. J Cell Biol 208(6)777-89 (PubMed)
RASSF5 Gene Information
- HGNC symbol
- RASSF5
- Aliases
- Maxp1; NORE1; RAPL
- Common name
- Ras association domain family member 5
- Entrez Id
- 83593
- Description
- This gene is a member of the Ras association domain family. It functions as a tumor suppressor, and is inactivated in a variety of cancers. The encoded protein localizes to centrosomes and microtubules, and associates with the GTP-activated forms of Ras, Rap1, and several other Ras-like small GTPases. The protein regulates lymphocyte adhesion and suppresses cell growth in response to activated Rap1 or Ras. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
RASSF5 Ontologies
- Gene Ontology
-
Process: GO:6915; apoptotic process
GO:7165; signal transduction
GO:42981; regulation of apoptotic process
GO:8285; negative regulation of cell population proliferation
GO:31398; positive regulation of protein ubiquitination
GO:1900180; regulation of protein localization to nucleus
Cellular component: GO:5737; cytoplasm
GO:5856; cytoskeleton
GO:5874; microtubule
GO:5634; nucleus
Show all GO termsFunction: GO:46872; metal ion binding
GO:5515; protein binding
GO:31267; small GTPase binding
GO:42802; identical protein binding
Homologs of RASSF5 in Model Organisms
- Caenorhabditis elegans
- rsf-1
- Danio rerio
- CR848745.1
- Mus musculus
- Rassf5
- Rattus norvegicus
- Rassf5
External links
- OMIM
- 607020
- Ensembl
- ENSG00000266094
- Entrez Gene
- 83593
- UniGene
- 497579
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- RASSF5
- GeneCards
- RASSF5