Cell Senescence Entries for RB1

Cell Types
Osteoblast
Cell Lines
Primary cell
Cancer Cell?
No
Method
Knockdown
Type of senescence
Stress-induced
Senescence Effect
Induces
Primary Reference
Kansara et al. (2014) Immune response to RB1-regulated senescence limits radiation-induced osteosarcoma formation. J Clin Invest 123(12)5351-60 (PubMed)

RB1 Gene Information

HGNC symbol
RB1 
Aliases
OSRC; PPP1R130; RB 
Common name
RB transcriptional corepressor 1 
Entrez Id
5925
Description
The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma. [provided by RefSeq, Jul 2008].

RB1 Ontologies

Gene Ontology
Process: GO:7049; cell cycle
GO:6357; regulation of transcription by RNA polymerase II
GO:6325; chromatin organization
GO:51726; regulation of cell cycle
GO:45892; negative regulation of transcription, DNA-templated
GO:6355; regulation of transcription, DNA-templated
GO:82; G1/S transition of mitotic cell cycle
GO:122; negative regulation of transcription by RNA polymerase II
GO:1558; regulation of cell growth
GO:1894; tissue homeostasis
GO:2062; chondrocyte differentiation
And 55 more GO terms
Cellular component: GO:5634; nucleus
GO:43229; intracellular organelle
GO:16605; PML body
GO:5667; transcription regulator complex
GO:5819; spindle
GO:35189; Rb-E2F complex
GO:5654; nucleoplasm
GO:5829; cytosol
GO:785; chromatin
GO:16514; SWI/SNF complex
GO:8024; cyclin/CDK positive transcription elongation factor complex
And 3 more GO terms
Function: GO:5515; protein binding
GO:3677; DNA binding
GO:31625; ubiquitin protein ligase binding
GO:19899; enzyme binding
GO:61629; RNA polymerase II-specific DNA-binding transcription factor binding
GO:140297; DNA-binding transcription factor binding
GO:42802; identical protein binding
GO:977; RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:51219; phosphoprotein binding
GO:19900; kinase binding
GO:97718; disordered domain specific binding
And 4 more GO terms
Show all GO terms

Homologs of RB1 in Model Organisms

Danio rerio
rb1
Mus musculus
Rb1
Rattus norvegicus
Rb1

In other databases

GenAge human genes
  • This gene is present as RB1

External links

OMIM
614041
Ensembl
ENSG00000139687
Entrez Gene
5925
UniGene
408528
1000 Genomes
1000 Genomes
HPRD
GenAtlas
RB1
GeneCards
RB1