Cell Senescence Entries for RBBP4

Cell Types
Lung fibroblast
Cell Lines
TIG-1
Cancer Cell?
No
Method
Knockdown
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Tsujii et al. (2016) Retinoblastoma-binding Protein 4-regulated Classical Nuclear Transport Is Involved in Cellular Senescence. J Biol Chem 290(49)29375-88 (PubMed)

RBBP4 Gene Information

HGNC symbol
RBBP4 
Aliases
lin-53; NURF55; RbAp48 
Common name
RB binding protein 4, chromatin remodeling factor 
Entrez Id
5928
Description
This gene encodes a ubiquitously expressed nuclear protein which belongs to a highly conserved subfamily of WD-repeat proteins. It is present in protein complexes involved in histone acetylation and chromatin assembly. It is part of the Mi-2 complex which has been implicated in chromatin remodeling and transcriptional repression associated with histone deacetylation. This encoded protein is also part of co-repressor complexes, which is an integral component of transcriptional silencing. It is found among several cellular proteins that bind directly to retinoblastoma protein to regulate cell proliferation. This protein also seems to be involved in transcriptional repression of E2F-responsive genes. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008].

RBBP4 Ontologies

Gene Ontology
Process: GO:7049; cell cycle
GO:6325; chromatin organization
GO:6260; DNA replication
GO:6338; chromatin remodeling
GO:10468; regulation of gene expression
GO:122; negative regulation of transcription by RNA polymerase II
GO:6355; regulation of transcription, DNA-templated
GO:45893; positive regulation of transcription, DNA-templated
GO:8285; negative regulation of cell population proliferation
GO:6335; DNA replication-dependent nucleosome assembly
GO:6336; DNA replication-independent nucleosome assembly
And 11 more GO terms
Cellular component: GO:5634; nucleus
GO:32991; protein-containing complex
GO:5654; nucleoplasm
GO:5829; cytosol
GO:785; chromatin
GO:781; chromosome, telomeric region
GO:118; histone deacetylase complex
GO:35098; ESC/E(Z) complex
GO:16589; NURF complex
GO:16581; NuRD complex
GO:1904949; ATPase complex
And 3 more GO terms
Function: GO:5515; protein binding
GO:42393; histone binding
GO:42826; histone deacetylase binding
GO:31492; nucleosomal DNA binding
GO:8094; ATPase, acting on DNA
GO:978; RNA polymerase II cis-regulatory region sequence-specific DNA binding
Show all GO terms

Homologs of RBBP4 in Model Organisms

Danio rerio
rbbp4
Drosophila melanogaster
Caf1
Mus musculus
Rbbp4
Rattus norvegicus
Rbbp4

External links

OMIM
602923
Ensembl
ENSG00000162521
Entrez Gene
5928
UniGene
16003
1000 Genomes
1000 Genomes
HPRD
GenAtlas
RBBP4
GeneCards
RBBP4