Cell Senescence Entries for RBL1

Cell Types
Prostate cancer
Cell Lines
DU145
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Stress-induced
Senescence Effect
Induces
Primary Reference
Lehmann et al. (2008) Distinct roles for p107 and p130 in Rb-independent cellular senescence. Cell Cycle 7(9)1262-8 (PubMed)

RBL1 Gene Information

HGNC symbol
RBL1 
Aliases
cp107; p107; PRB1 
Common name
RB transcriptional corepressor like 1 
Entrez Id
5933
Description
The protein encoded by this gene is similar in sequence and possibly function to the product of the retinoblastoma 1 (RB1) gene. The RB1 gene product is a tumor suppressor protein that appears to be involved in cell cycle regulation, as it is phosphorylated in the S to M phase transition and is dephosphorylated in the G1 phase of the cell cycle. Both the RB1 protein and the product of this gene can form a complex with adenovirus E1A protein and SV40 large T-antigen, with the SV40 large T-antigen binding only to the unphosphorylated form of each protein. In addition, both proteins can inhibit the transcription of cell cycle genes containing E2F binding sites in their promoters. Due to the sequence and biochemical similarities with the RB1 protein, it is thought that the protein encoded by this gene may also be a tumor suppressor. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

RBL1 Ontologies

Gene Ontology
Process: GO:2000773; negative regulation of cellular senescence
GO:7049; cell cycle
GO:6357; regulation of transcription by RNA polymerase II
GO:6325; chromatin organization
GO:51726; regulation of cell cycle
GO:30154; cell differentiation
GO:51302; regulation of cell division
GO:2000134; negative regulation of G1/S transition of mitotic cell cycle
GO:10629; negative regulation of gene expression
GO:43550; regulation of lipid kinase activity
GO:122; negative regulation of transcription by RNA polymerase II
And 1 more GO terms
Cellular component: GO:5634; nucleus
GO:5654; nucleoplasm
GO:5667; transcription regulator complex
GO:785; chromatin
Function: GO:5515; protein binding
GO:977; RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:1990841; promoter-specific chromatin binding
Show all GO terms

Homologs of RBL1 in Model Organisms

Caenorhabditis elegans
lin-35
Danio rerio
rbl1
Mus musculus
Rbl1
Rattus norvegicus
Rbl1

In other databases

CellAge gene expression
  • This gene is present as RBL1

External links

OMIM
116957
Ensembl
ENSG00000080839
Entrez Gene
5933
UniGene
207745
1000 Genomes
1000 Genomes
HPRD
GenAtlas
RBL1
GeneCards
RBL1