Cell Senescence Entries for RBP1

Cell Types
Cervical cancer, Lung cancer
Cell Lines
C-33A, H1299
Cancer Cell?
Yes
Method
Mutation, Overexpression
Type of senescence
Oncogene-induced
Senescence Effect
Induces
Primary Reference
Binda et al. (2006) RBP1 family proteins exhibit SUMOylation-dependent transcriptional repression and induce cell growth inhibition reminiscent of senescence. Mol Cell Biol 26(5)1917-31 (PubMed)

RBP1 Gene Information

HGNC symbol
RBP1 
Aliases
CRABP-I; CRBP; CRBP1; CRBPI; RBPC 
Common name
retinol binding protein 1 
Entrez Id
5947
Description
This gene encodes the carrier protein involved in the transport of retinol (vitamin A alcohol) from the liver storage site to peripheral tissue. Vitamin A is a fat-soluble vitamin necessary for growth, reproduction, differentiation of epithelial tissues, and vision. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008].

RBP1 Ontologies

Gene Ontology
Process: GO:2138; retinoic acid biosynthetic process
GO:6776; vitamin A metabolic process
GO:30852; regulation of granulocyte differentiation
GO:33189; response to vitamin A
GO:42572; retinol metabolic process
GO:42573; retinoic acid metabolic process
GO:15908; fatty acid transport
GO:55088; lipid homeostasis
Cellular component: GO:5654; nucleoplasm
GO:5829; cytosol
GO:5811; lipid droplet
GO:44297; cell body
GO:5737; cytoplasm
GO:5634; nucleus
Function: GO:8289; lipid binding
GO:19841; retinol binding
GO:5515; protein binding
GO:5504; fatty acid binding
GO:16918; retinal binding
GO:5501; retinoid binding
GO:1904768; all-trans-retinol binding
Show all GO terms

Homologs of RBP1 in Model Organisms

Danio rerio
si:ch211-119o8.7
Mus musculus
Rbp1
Rattus norvegicus
Rbp1

In other databases

CellAge gene expression
  • This gene is present as RBP1

External links

OMIM
180260
Ensembl
ENSG00000114115
Entrez Gene
5947
UniGene
708528
1000 Genomes
1000 Genomes
HPRD
GenAtlas
RBP1
GeneCards
RBP1