Cell Senescence Entries for RBX1

Cell Types
Glioblastoma
Cell Lines
U87
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Jia et al. (2009) ROC1/RBX1 E3 ubiquitin ligase silencing suppresses tumor cell growth via sequential induction of G2-M arrest, apoptosis, and senescence. Cancer Res 69(12)4974-82 (PubMed)

RBX1 Gene Information

HGNC symbol
RBX1 
Aliases
BA554C12.1; RNF75; ROC1 
Common name
ring-box 1 
Entrez Id
9978
Description
This locus encodes a RING finger-like domain-containing protein. The encoded protein interacts with cullin proteins and likely plays a role in ubiquitination processes necessary for cell cycle progression. This protein may also affect protein turnover. Related pseudogenes exist on chromosomes 2 and 5.[provided by RefSeq, Sep 2010].

RBX1 Ontologies

Gene Ontology
Process: GO:16567; protein ubiquitination
GO:6281; DNA repair
GO:6974; cellular response to DNA damage stimulus
GO:43161; proteasome-mediated ubiquitin-dependent protein catabolic process
GO:209; protein polyubiquitination
GO:31146; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:6511; ubiquitin-dependent protein catabolic process
GO:70936; protein K48-linked ubiquitination
GO:45116; protein neddylation
GO:6513; protein monoubiquitination
GO:32436; positive regulation of proteasomal ubiquitin-dependent protein catabolic process
And 8 more GO terms
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:5654; nucleoplasm
GO:5829; cytosol
GO:31463; Cul3-RING ubiquitin ligase complex
GO:19005; SCF ubiquitin ligase complex
GO:31466; Cul5-RING ubiquitin ligase complex
GO:31461; cullin-RING ubiquitin ligase complex
GO:31462; Cul2-RING ubiquitin ligase complex
GO:31464; Cul4A-RING E3 ubiquitin ligase complex
GO:31465; Cul4B-RING E3 ubiquitin ligase complex
And 2 more GO terms
Function: GO:8270; zinc ion binding
GO:46872; metal ion binding
GO:16740; transferase activity
GO:31625; ubiquitin protein ligase binding
GO:5515; protein binding
GO:4842; ubiquitin-protein transferase activity
GO:97602; cullin family protein binding
GO:61630; ubiquitin protein ligase activity
GO:61629; RNA polymerase II-specific DNA-binding transcription factor binding
GO:19788; NEDD8 transferase activity
GO:34450; ubiquitin-ubiquitin ligase activity
And 2 more GO terms
Show all GO terms

Homologs of RBX1 in Model Organisms

Caenorhabditis elegans
rbx-1
Danio rerio
rbx1
Drosophila melanogaster
Roc1a
Mus musculus
Rbx1
Rattus norvegicus
Rbx1
Saccharomyces cerevisiae
HRT1
Schizosaccharomyces pombe
pip1

External links

OMIM
603814
Ensembl
ENSG00000100387
Entrez Gene
9978
UniGene
474949
1000 Genomes
1000 Genomes
HPRD
GenAtlas
RBX1
GeneCards
RBX1