Cell Senescence Entries for RELA

Cell Types
Cervical cancer
Cell Lines
HeLa
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Stress-induced
Senescence Effect
Induces
Primary Reference
Zhi et al. (2011) NF-κB hyper-activation by HTLV-1 tax induces cellular senescence, but can be alleviated by the viral anti-sense protein HBZ. PLoS Pathog 7(4)e1002025 (PubMed)

RELA Gene Information

HGNC symbol
RELA 
Aliases
NFKB3; p65 
Common name
RELA proto-oncogene, NF-kB subunit 
Entrez Id
5970
Description
NF-kappa-B is a ubiquitous transcription factor involved in several biological processes. It is held in the cytoplasm in an inactive state by specific inhibitors. Upon degradation of the inhibitor, NF-kappa-B moves to the nucleus and activates transcription of specific genes. NF-kappa-B is composed of NFKB1 or NFKB2 bound to either REL, RELA, or RELB. The most abundant form of NF-kappa-B is NFKB1 complexed with the product of this gene, RELA. Four transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011].

RELA Ontologies

Gene Ontology
Process: GO:6355; regulation of transcription, DNA-templated
GO:51092; positive regulation of NF-kappaB transcription factor activity
GO:32479; regulation of type I interferon production
GO:43066; negative regulation of apoptotic process
GO:45892; negative regulation of transcription, DNA-templated
GO:43123; positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:45944; positive regulation of transcription by RNA polymerase II
GO:45893; positive regulation of transcription, DNA-templated
GO:51607; defense response to virus
GO:6954; inflammatory response
GO:10033; response to organic substance
And 57 more GO terms
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:5829; cytosol
GO:71159; NF-kappaB complex
GO:785; chromatin
GO:5654; nucleoplasm
GO:5667; transcription regulator complex
GO:35525; NF-kappaB p50/p65 complex
GO:98978; glutamatergic synapse
Function: GO:3677; DNA binding
GO:3700; DNA-binding transcription factor activity
GO:978; RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:31625; ubiquitin protein ligase binding
GO:42802; identical protein binding
GO:31490; chromatin DNA binding
GO:42803; protein homodimerization activity
GO:5515; protein binding
GO:981; DNA-binding transcription factor activity, RNA polymerase II-specific
GO:977; RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:976; transcription cis-regulatory region binding
And 18 more GO terms
Show all GO terms

Homologs of RELA in Model Organisms

Danio rerio
rela
Drosophila melanogaster
Dif
Mus musculus
Rela
Rattus norvegicus
Rela

In other databases

GenAge human genes
  • This gene is present as RELA

External links

OMIM
164014
Ensembl
ENSG00000173039
Entrez Gene
5970
UniGene
502875
1000 Genomes
1000 Genomes
HPRD
GenAtlas
RELA
GeneCards
RELA