Cell Senescence Entries for RHOA

Cell Types
Mammary epithelial
Cell Lines
Primary cell
Cancer Cell?
No
Method
Overexpression
Type of senescence
Oncogene-induced
Senescence Effect
Inhibits
Primary Reference
Zhao et al. (2009) Overexpression of RhoA induces preneoplastic transformation of primary mammary epithelial cells. Cancer Res 69(2)483-91 (PubMed)

RHOA Gene Information

HGNC symbol
RHOA 
Aliases
ARH12; ARHA; Rho12; RHOH12 
Common name
ras homolog family member A 
Entrez Id
387
Description
This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. Overexpression of this gene is associated with tumor cell proliferation and metastasis. Multiple alternatively spliced variants have been identified. [provided by RefSeq, Sep 2015].

RHOA Ontologies

Gene Ontology
Process: GO:7264; small GTPase mediated signal transduction
GO:7049; cell cycle
GO:30036; actin cytoskeleton organization
GO:51301; cell division
GO:43123; positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:44319; wound healing, spreading of cells
GO:1902766; skeletal muscle satellite cell migration
GO:7266; Rho protein signal transduction
GO:32956; regulation of actin cytoskeleton organization
GO:71222; cellular response to lipopolysaccharide
GO:71902; positive regulation of protein serine/threonine kinase activity
And 96 more GO terms
Cellular component: GO:5737; cytoplasm
GO:16020; membrane
GO:5886; plasma membrane
GO:5856; cytoskeleton
GO:5925; focal adhesion
GO:5829; cytosol
GO:42995; cell projection
GO:30425; dendrite
GO:71944; cell periphery
GO:5938; cell cortex
GO:30027; lamellipodium
And 19 more GO terms
Function: GO:3924; GTPase activity
GO:5525; GTP binding
GO:5515; protein binding
GO:166; nucleotide binding
GO:16787; hydrolase activity
GO:3925; G protein activity
GO:19901; protein kinase binding
GO:17022; myosin binding
GO:19003; GDP binding
GO:19904; protein domain specific binding
GO:51022; Rho GDP-dissociation inhibitor binding
And 1 more GO terms
Show all GO terms

Homologs of RHOA in Model Organisms

Danio rerio
rhoab
Mus musculus
Rhoa
Rattus norvegicus
Rhoa

In other databases

LongevityMap
  • This gene is present as RHOA

External links

OMIM
165390
Ensembl
ENSG00000067560
Entrez Gene
387
UniGene
247077
1000 Genomes
1000 Genomes
HPRD
GenAtlas
RHOA
GeneCards
RHOA