Cell Senescence Entries for RNASEL

Cell Types
Lung fibroblast
Cell Lines
WI-38
Cancer Cell?
No
Method
Knockout, Overexpression
Type of senescence
Replicative
Senescence Effect
Induces
Primary Reference
Andersen et al. (2007) Role of 2-5A-dependent RNase-L in senescence and longevity. Oncogene 26(21)3081-8 (PubMed)

RNASEL Gene Information

HGNC symbol
RNASEL 
Aliases
PRCA1; RNS4 
Common name
ribonuclease L 
Entrez Id
6041
Description
This gene encodes a component of the interferon-regulated 2-5A system that functions in the antiviral and antiproliferative roles of interferons. The protein is involved in innate immunity and is active against multiple RNA viruses, including the influenza and SARS-CoV-2 viruses. Mutations in this gene have been associated with predisposition to prostate cancer and this gene is a candidate for the hereditary prostate cancer 1 (HPC1) allele. [provided by RefSeq, Nov 2021].

RNASEL Ontologies

Gene Ontology
Process: GO:90502; RNA phosphodiester bond hydrolysis, endonucleolytic
GO:90501; RNA phosphodiester bond hydrolysis
GO:6468; protein phosphorylation
GO:90305; nucleic acid phosphodiester bond hydrolysis
GO:45944; positive regulation of transcription by RNA polymerase II
GO:6397; mRNA processing
GO:51607; defense response to virus
GO:45071; negative regulation of viral genome replication
GO:6396; RNA processing
GO:6364; rRNA processing
GO:43488; regulation of mRNA stability
And 3 more GO terms
Cellular component: GO:5737; cytoplasm
GO:5739; mitochondrion
GO:5829; cytosol
GO:5575; cellular_component
GO:5759; mitochondrial matrix
GO:16363; nuclear matrix
Function: GO:3723; RNA binding
GO:46872; metal ion binding
GO:166; nucleotide binding
GO:4672; protein kinase activity
GO:5524; ATP binding
GO:16787; hydrolase activity
GO:4518; nuclease activity
GO:5515; protein binding
GO:4519; endonuclease activity
GO:42802; identical protein binding
GO:4521; endoribonuclease activity
And 4 more GO terms
Show all GO terms

Homologs of RNASEL in Model Organisms

Danio rerio
CU929396.1
Mus musculus
Rnasel
Rattus norvegicus
Rnasel

External links

OMIM
180435
Ensembl
ENSG00000135828
Entrez Gene
6041
UniGene
518545
1000 Genomes
1000 Genomes
HPRD
GenAtlas
RNASEL
GeneCards
RNASEL