Cell Senescence Entries for RPS14

Cell Types
Glioblastoma, Lung cancer, Lung fibroblast, Prostate cancer
Cell Lines
H1299, IMR-90, PC-3, U87
Cancer Cell?
Yes
Method
Overexpression
Type of senescence
Oncogene-induced
Senescence Effect
Induces
Primary Reference
Lessard et al. (2019) Senescence-associated ribosome biogenesis defects contributes to cell cycle arrest through the Rb pathway. Nat Cell Biol 20(7)789-799 (PubMed)

RPS14 Gene Information

HGNC symbol
RPS14 
Aliases
EMTB; S14 
Common name
ribosomal protein S14 
Entrez Id
6208
Description
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S11P family of ribosomal proteins. It is located in the cytoplasm. Transcript variants utilizing alternative transcription initiation sites have been described in the literature. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. In Chinese hamster ovary cells, mutations in this gene can lead to resistance to emetine, a protein synthesis inhibitor. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008].

RPS14 Ontologies

Gene Ontology
Process: GO:6412; translation
GO:122; negative regulation of transcription by RNA polymerase II
GO:28; ribosomal small subunit assembly
GO:462; maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:30218; erythrocyte differentiation
GO:30490; maturation of SSU-rRNA
GO:6417; regulation of translation
GO:2181; cytoplasmic translation
Cellular component: GO:16020; membrane
GO:5840; ribosome
GO:5925; focal adhesion
GO:5730; nucleolus
GO:22627; cytosolic small ribosomal subunit
GO:5654; nucleoplasm
GO:5829; cytosol
GO:70062; extracellular exosome
GO:22626; cytosolic ribosome
GO:14069; postsynaptic density
GO:5737; cytoplasm
And 1 more GO terms
Function: GO:3723; RNA binding
GO:3735; structural constituent of ribosome
GO:5515; protein binding
GO:48027; mRNA 5'-UTR binding
GO:45182; translation regulator activity
GO:70181; small ribosomal subunit rRNA binding
Show all GO terms

Homologs of RPS14 in Model Organisms

Caenorhabditis elegans
rps-14
Danio rerio
rps14
Drosophila melanogaster
RpS14a
Mus musculus
Rps14
Rattus norvegicus
Rps14
Saccharomyces cerevisiae
RPS14B
Schizosaccharomyces pombe
rps14a

In other databases

GenAge model organism genes
  • A homolog of this gene for Caenorhabditis elegans is present as rps-14

External links

OMIM
130620
Ensembl
ENSG00000164587
Entrez Gene
6208
UniGene
744846
1000 Genomes
1000 Genomes
HPRD
GenAtlas
RPS14
GeneCards
RPS14