Cell Senescence Entries for RRM2B
- Cell Types
- Lung fibroblast
- Cell Lines
- IMR-90
- Cancer Cell?
- No
- Method
- Knockdown
- Type of senescence
- Unclear
- Senescence Effect
- Inhibits
- Primary Reference
- Kuo et al. (2013) RRM2B suppresses activation of the oxidative stress pathway and is up-regulated by p53 during senescence. Sci Rep 2(2)822 (PubMed)
RRM2B Gene Information
- HGNC symbol
- RRM2B
- Aliases
- p53R2
- Common name
- ribonucleotide reductase regulatory TP53 inducible subunit M2B
- Entrez Id
- 50484
- Description
- This gene encodes the small subunit of a p53-inducible ribonucleotide reductase. This heterotetrameric enzyme catalyzes the conversion of ribonucleoside diphosphates to deoxyribonucleoside diphosphates. The product of this reaction is necessary for DNA synthesis. Mutations in this gene have been associated with autosomal recessive mitochondrial DNA depletion syndrome, autosomal dominant progressive external ophthalmoplegia-5, and mitochondrial neurogastrointestinal encephalopathy. Alternatively spliced transcript variants have been described.[provided by RefSeq, Feb 2010].
RRM2B Ontologies
- Gene Ontology
-
Process: GO:6281; DNA repair
GO:6974; cellular response to DNA damage stimulus
GO:6260; DNA replication
GO:9263; deoxyribonucleotide biosynthetic process
GO:6264; mitochondrial DNA replication
GO:9185; ribonucleoside diphosphate metabolic process
GO:9265; 2'-deoxyribonucleotide biosynthetic process
GO:10971; positive regulation of G2/M transition of mitotic cell cycle
GO:70318; positive regulation of G0 to G1 transition
GO:1822; kidney development
GO:3014; renal system process
And 7 more GO terms Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:5654; nucleoplasm
GO:5829; cytosol
GO:5739; mitochondrion
GO:5971; ribonucleoside-diphosphate reductase complex
GO:16020; membrane
GO:16021; integral component of membrane
Show all GO termsFunction: GO:46872; metal ion binding
GO:16491; oxidoreductase activity
GO:5515; protein binding
GO:42802; identical protein binding
GO:4748; ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor
Homologs of RRM2B in Model Organisms
- Drosophila melanogaster
- RnrS
- Mus musculus
- Rrm2b
- Rattus norvegicus
- Rrm2b
- Saccharomyces cerevisiae
- RNR2
- Schizosaccharomyces pombe
- suc22
In other databases
- CellAge gene expression
- This gene is present as RRM2B
External links
- OMIM
- 604712
- Ensembl
- ENSG00000048392
- Entrez Gene
- 50484
- UniGene
- 512592
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- RRM2B
- GeneCards
- RRM2B