Cell Senescence Entries for RRP8

Cell Types
Lung cancer
Cell Lines
A549
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Stress-induced
Senescence Effect
Induces
Primary Reference
Yang et al. (2016) Nucleolar repression facilitates initiation and maintenance of senescence. Cell Cycle 14(22)3613-23 (PubMed)

RRP8 Gene Information

HGNC symbol
RRP8 
Aliases
KIAA0409; NML 
Common name
ribosomal RNA processing 8 
Entrez Id
23378
Description

RRP8 Ontologies

Gene Ontology
Process: GO:32259; methylation
GO:6325; chromatin organization
GO:6364; rRNA processing
GO:42149; cellular response to glucose starvation
GO:45892; negative regulation of transcription, DNA-templated
GO:1903450; regulation of G1 to G0 transition
GO:183; rDNA heterochromatin assembly
GO:31062; positive regulation of histone methylation
GO:31065; positive regulation of histone deacetylation
GO:45786; negative regulation of cell cycle
GO:46015; regulation of transcription by glucose
And 3 more GO terms
Cellular component: GO:5634; nucleus
GO:5654; nucleoplasm
GO:5730; nucleolus
GO:5829; cytosol
GO:5886; plasma membrane
GO:33553; rDNA heterochromatin
GO:61773; eNoSc complex
GO:5677; chromatin silencing complex
Function: GO:3723; RNA binding
GO:16740; transferase activity
GO:8168; methyltransferase activity
GO:5515; protein binding
GO:35064; methylated histone binding
GO:8757; S-adenosylmethionine-dependent methyltransferase activity
Show all GO terms

Homologs of RRP8 in Model Organisms

Caenorhabditis elegans
T07A9.8
Danio rerio
wu:fk33d07
Drosophila melanogaster
CG7137
Mus musculus
Rrp8
Rattus norvegicus
Rrp8
Saccharomyces cerevisiae
RRP8
Schizosaccharomyces pombe
rrp8

In other databases

GenAge model organism genes
  • A homolog of this gene for Caenorhabditis elegans is present as T07A9.8
  • A homolog of this gene for Saccharomyces cerevisiae is present as RRP8

External links

OMIM
615818
Ensembl
ENSG00000132275
Entrez Gene
23378
UniGene
652255
1000 Genomes
1000 Genomes
HPRD
GenAtlas
RRP8
GeneCards
RRP8