Cell Senescence Entries for RTN4

Cell Types
Prostate cancer
Cell Lines
DU145
Cancer Cell?
Yes
Method
Overexpression
Type of senescence
Unclear
Senescence Effect
Induces
Primary Reference
Zhao et al. (2020) Cell fate regulation by reticulon-4 in human prostate cancers. J Cell Physiol 234(7)10372-10385 (PubMed)

RTN4 Gene Information

HGNC symbol
RTN4 
Aliases
ASY; KIAA0886; NOGO; NSP-CL 
Common name
reticulon 4 
Entrez Id
57142
Description
This gene belongs to the family of reticulon encoding genes. Reticulons are associated with the endoplasmic reticulum, and are involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. The product of this gene is a potent neurite outgrowth inhibitor which may also help block the regeneration of the central nervous system in higher vertebrates. Alternatively spliced transcript variants derived both from differential splicing and differential promoter usage and encoding different isoforms have been identified. [provided by RefSeq, Jul 2008].

RTN4 Ontologies

Gene Ontology
Process: GO:6915; apoptotic process
GO:7399; nervous system development
GO:42981; regulation of apoptotic process
GO:71456; cellular response to hypoxia
GO:61462; protein localization to lysosome
GO:1902430; negative regulation of amyloid-beta formation
GO:71786; endoplasmic reticulum tubular network organization
GO:71787; endoplasmic reticulum tubular network formation
GO:50821; protein stabilization
GO:34165; positive regulation of toll-like receptor 9 signaling pathway
GO:30517; negative regulation of axon extension
And 30 more GO terms
Cellular component: GO:16020; membrane
GO:16021; integral component of membrane
GO:5783; endoplasmic reticulum
GO:5789; endoplasmic reticulum membrane
GO:5886; plasma membrane
GO:5635; nuclear envelope
GO:30054; cell junction
GO:30176; integral component of endoplasmic reticulum membrane
GO:98826; endoplasmic reticulum tubular network membrane
GO:71782; endoplasmic reticulum tubular network
GO:14069; postsynaptic density
And 3 more GO terms
Function: GO:3723; RNA binding
GO:5515; protein binding
GO:45296; cadherin binding
GO:31625; ubiquitin protein ligase binding
GO:42803; protein homodimerization activity
Show all GO terms

Homologs of RTN4 in Model Organisms

Caenorhabditis elegans
ret-1
Drosophila melanogaster
Rtnl1
Mus musculus
Rtn4
Rattus norvegicus
Rtn4

External links

OMIM
604475
Ensembl
ENSG00000115310
Entrez Gene
57142
UniGene
637850
1000 Genomes
1000 Genomes
HPRD
GenAtlas
RTN4
GeneCards
RTN4