Cell Senescence Entries for SALL1

Cell Types
Breast cancer
Cell Lines
E0771, MCF-7, MDA-MB-231
Cancer Cell?
Yes
Method
Overexpression
Type of senescence
Oncogene-induced
Senescence Effect
Induces
Primary Reference
Ma et al. (2019) SALL1 functions as a tumor suppressor in breast cancer by regulating cancer cell senescence and metastasis through the NuRD complex. Mol Cancer 17(1)78 (PubMed)

SALL1 Gene Information

HGNC symbol
SALL1 
Aliases
Hsal1; TBS; ZNF794 
Common name
spalt like transcription factor 1 
Entrez Id
6299
Description
The protein encoded by this gene is a zinc finger transcriptional repressor and may be part of the NuRD histone deacetylase complex (HDAC). Defects in this gene are a cause of Townes-Brocks syndrome (TBS) as well as bronchio-oto-renal syndrome (BOR). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

SALL1 Ontologies

Gene Ontology
Process: GO:45892; negative regulation of transcription, DNA-templated
GO:45944; positive regulation of transcription by RNA polymerase II
GO:45893; positive regulation of transcription, DNA-templated
GO:122; negative regulation of transcription by RNA polymerase II
GO:1822; kidney development
GO:30177; positive regulation of Wnt signaling pathway
GO:6357; regulation of transcription by RNA polymerase II
GO:7507; heart development
GO:42733; embryonic digit morphogenesis
GO:60173; limb development
GO:1657; ureteric bud development
And 14 more GO terms
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:5654; nucleoplasm
GO:792; heterochromatin
GO:10369; chromocenter
Function: GO:46872; metal ion binding
GO:3677; DNA binding
GO:5515; protein binding
GO:981; DNA-binding transcription factor activity, RNA polymerase II-specific
GO:978; RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:8013; beta-catenin binding
GO:1227; DNA-binding transcription repressor activity, RNA polymerase II-specific
Show all GO terms

Homologs of SALL1 in Model Organisms

Danio rerio
sall1a
Mus musculus
Sall1
Rattus norvegicus
Sall1

External links

OMIM
602218
Ensembl
ENSG00000103449
Entrez Gene
6299
UniGene
135787
1000 Genomes
1000 Genomes
HPRD
GenAtlas
SALL1
GeneCards
SALL1