Cell Senescence Entries for SDC1

Cell Types
Prostate cancer
Cell Lines
PC-3
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Fujii et al. (2015) Syndecan-1 responsive microRNA-126 and 149 regulate cell proliferation in prostate cancer. Biochem Biophys Res Commun 456(1)183-9 (PubMed)

SDC1 Gene Information

HGNC symbol
SDC1 
Aliases
CD138; SDC; SYND1; syndecan 
Common name
syndecan 1 
Entrez Id
6382
Description
The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-1 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-1 expression has been detected in several different tumor types. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same protein. [provided by RefSeq, Jul 2008].

SDC1 Ontologies

Gene Ontology
Process: GO:16477; cell migration
GO:42060; wound healing
GO:1903543; positive regulation of exosomal secretion
GO:1903553; positive regulation of extracellular exosome assembly
GO:1657; ureteric bud development
GO:6954; inflammatory response
GO:9636; response to toxic substance
GO:10033; response to organic substance
GO:42476; odontogenesis
GO:42542; response to hydrogen peroxide
GO:48627; myoblast development
And 7 more GO terms
Cellular component: GO:16020; membrane
GO:16021; integral component of membrane
GO:5576; extracellular region
GO:9986; cell surface
GO:5886; plasma membrane
GO:70062; extracellular exosome
GO:5887; integral component of plasma membrane
GO:43202; lysosomal lumen
GO:5796; Golgi lumen
GO:9897; external side of plasma membrane
GO:32991; protein-containing complex
And 1 more GO terms
Function: GO:5515; protein binding
GO:42802; identical protein binding
GO:8022; protein C-terminus binding
Show all GO terms

Homologs of SDC1 in Model Organisms

Caenorhabditis elegans
sdn-1
Mus musculus
Sdc1
Rattus norvegicus
Sdc1

External links

OMIM
186355
Ensembl
ENSG00000115884
Entrez Gene
6382
UniGene
665958
1000 Genomes
1000 Genomes
HPRD
GenAtlas
SDC1
GeneCards
SDC1