The SELENOH gene and its putative association with human ageing

Cell Senescence Entries for SELENOH

Cell Types: Lung fibroblast
Cell Lines: MRC-5
Cancer Cell?: No
Method: Knockdown
Type of senescence: Stress-induced
Senescence Effect: Inhibits
Primary Reference: Wu et al. (2015) Selenoprotein H suppresses cellular senescence through genome maintenance and redox regulation. J Biol Chem 289(49)34378-88 (PubMed)

HGNC symbol: SELENOH
Aliases: C11orf31; SELH
Common name: selenoprotein H
Entrez Id: 280636
Description: This gene encodes a nucleolar protein, which belongs to the SelWTH family. It functions as an oxidoreductase, and has been shown to protect neurons against UVB-induced damage by inhibiting apoptotic cell death pathways, promote mitochondrial biogenesis and mitochondrial function, and suppress cellular senescence through genome maintenance and redox regulation. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, May 2016].

Gene Ontology

Process:

Cellular component:

GO:5794; Golgi apparatus

Function:

GO:3723; RNA binding

Show all GO terms