Cell Senescence Entries for SGK1

Cell Types
Umbilical vein endothelial
Cell Lines
Primary cell
Cancer Cell?
No
Method
Overexpression
Type of senescence
Replicative
Senescence Effect
Inhibits
Primary Reference
Basello et al. (2016) Serum- and Glucocorticoid-Inducible Kinase 1 Delay the Onset of Endothelial Senescence by Directly Interacting with Human Telomerase Reverse Transcriptase. Rejuvenation Res 19(1)79-89 (PubMed)

SGK1 Gene Information

HGNC symbol
SGK1 
Aliases
SGK 
Common name
serum/glucocorticoid regulated kinase 1 
Entrez Id
6446
Description
This gene encodes a serine/threonine protein kinase that plays an important role in cellular stress response. This kinase activates certain potassium, sodium, and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability, and renal sodium excretion. High levels of expression of this gene may contribute to conditions such as hypertension and diabetic nephropathy. Several alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jan 2009].

SGK1 Ontologies

Gene Ontology
Process: GO:6468; protein phosphorylation
GO:16310; phosphorylation
GO:6915; apoptotic process
GO:42127; regulation of cell population proliferation
GO:42981; regulation of apoptotic process
GO:35556; intracellular signal transduction
GO:50790; regulation of catalytic activity
GO:30334; regulation of cell migration
GO:18105; peptidyl-serine phosphorylation
GO:1558; regulation of cell growth
GO:6814; sodium ion transport
And 11 more GO terms
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:16607; nuclear speck
GO:16020; membrane
GO:5783; endoplasmic reticulum
GO:5789; endoplasmic reticulum membrane
GO:5829; cytosol
GO:5886; plasma membrane
GO:5739; mitochondrion
GO:5654; nucleoplasm
Function: GO:166; nucleotide binding
GO:4672; protein kinase activity
GO:4674; protein serine/threonine kinase activity
GO:4712; protein serine/threonine/tyrosine kinase activity
GO:5524; ATP binding
GO:16301; kinase activity
GO:16740; transferase activity
GO:106310; protein serine kinase activity
GO:5515; protein binding
GO:15459; potassium channel regulator activity
GO:5246; calcium channel regulator activity
And 4 more GO terms
Show all GO terms

Homologs of SGK1 in Model Organisms

Danio rerio
sgk1
Mus musculus
Sgk1
Rattus norvegicus
Sgk1

In other databases

GenAge microarray genes
  • This gene is present as SGK1
LongevityMap
  • This gene is present as SGK1

External links

OMIM
602958
Ensembl
ENSG00000118515
Entrez Gene
6446
UniGene
510078
1000 Genomes
1000 Genomes
HPRD
GenAtlas
SGK1
GeneCards
SGK1