Cell Senescence Entries for SIX1

Cell Types
Lung fibroblast
Cell Lines
IMR-90
Cancer Cell?
No
Method
Knockdown
Type of senescence
Oncogene-induced
Senescence Effect
Inhibits
Primary Reference
Adrados et al. (2017) The homeoprotein SIX1 controls cellular senescence through the regulation of p16INK4A and differentiation-related genes. Oncogene 35(27)3485-94 (PubMed)

SIX1 Gene Information

HGNC symbol
SIX1 
Aliases
DFNA23 
Common name
SIX homeobox 1 
Entrez Id
6495
Description
The protein encoded by this gene is a homeobox protein that is similar to the Drosophila 'sine oculis' gene product. This gene is found in a cluster of related genes on chromosome 14 and is thought to be involved in limb development. Defects in this gene are a cause of autosomal dominant deafness type 23 (DFNA23) and branchiootic syndrome type 3 (BOS3). [provided by RefSeq, Jul 2008].

SIX1 Ontologies

Gene Ontology
Process: GO:6355; regulation of transcription, DNA-templated
GO:6915; apoptotic process
GO:45944; positive regulation of transcription by RNA polymerase II
GO:45892; negative regulation of transcription, DNA-templated
GO:45893; positive regulation of transcription, DNA-templated
GO:1822; kidney development
GO:6357; regulation of transcription by RNA polymerase II
GO:48699; generation of neurons
GO:7389; pattern specification process
GO:43524; negative regulation of neuron apoptotic process
GO:30855; epithelial cell differentiation
And 55 more GO terms
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:5654; nucleoplasm
GO:5730; nucleolus
GO:785; chromatin
GO:5667; transcription regulator complex
Function: GO:3677; DNA binding
GO:3700; DNA-binding transcription factor activity
GO:981; DNA-binding transcription factor activity, RNA polymerase II-specific
GO:43565; sequence-specific DNA binding
GO:5515; protein binding
GO:976; transcription cis-regulatory region binding
GO:978; RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:1990837; sequence-specific double-stranded DNA binding
GO:1228; DNA-binding transcription activator activity, RNA polymerase II-specific
GO:1223; transcription coactivator binding
GO:3682; chromatin binding
And 1 more GO terms
Show all GO terms

Homologs of SIX1 in Model Organisms

Danio rerio
six1b
Mus musculus
Six1
Rattus norvegicus
Six1

External links

OMIM
601205
Ensembl
ENSG00000126778
Entrez Gene
6495
UniGene
633506
1000 Genomes
1000 Genomes
HPRD
GenAtlas
SIX1
GeneCards
SIX1