Cell Senescence Entries for SLC13A3

Cell Types
Lung fibroblast, Renal tubular
Cell Lines
MRC-5, WI-38
Cancer Cell?
No
Method
Overexpression
Type of senescence
Stress-induced
Senescence Effect
Induces
Primary Reference
Ma et al. (2016) NaDC3 Induces Premature Cellular Senescence by Promoting Transport of Krebs Cycle Intermediates, Increasing NADH, and Exacerbating Oxidative Damage. J Gerontol A Biol Sci Med Sci 71(1)1-12 (PubMed)

SLC13A3 Gene Information

HGNC symbol
SLC13A3 
Aliases
NADC3; SDCT2 
Common name
solute carrier family 13 member 3 
Entrez Id
64849
Description
Mammalian sodium-dicarboxylate cotransporters transport succinate and other Krebs cycle intermediates. They fall into 2 categories based on their substrate affinity: low affinity and high affinity. Both the low- and high-affinity transporters play an important role in the handling of citrate by the kidneys. The protein encoded by this gene represents the high-affinity form. Alternatively spliced transcript variants encoding different isoforms have been found for this gene, although the full-length nature of some of them have not been characterized yet. [provided by RefSeq, Jul 2008].

SLC13A3 Ontologies

Gene Ontology
Process: GO:55085; transmembrane transport
GO:6811; ion transport
GO:6814; sodium ion transport
GO:150104; transport across blood-brain barrier
GO:34775; glutathione transmembrane transport
GO:15742; alpha-ketoglutarate transport
GO:71422; succinate transmembrane transport
GO:98656; anion transmembrane transport
GO:15746; citrate transport
GO:6835; dicarboxylic acid transport
Cellular component: GO:16020; membrane
GO:16021; integral component of membrane
GO:5886; plasma membrane
GO:70062; extracellular exosome
GO:16323; basolateral plasma membrane
Function: GO:22857; transmembrane transporter activity
GO:15293; symporter activity
GO:5515; protein binding
GO:34634; glutathione transmembrane transporter activity
GO:15141; succinate transmembrane transporter activity
GO:15137; citrate transmembrane transporter activity
GO:17153; sodium:dicarboxylate symporter activity
GO:5310; dicarboxylic acid transmembrane transporter activity
GO:15139; alpha-ketoglutarate transmembrane transporter activity
GO:15362; high-affinity sodium:dicarboxylate symporter activity
Show all GO terms

Homologs of SLC13A3 in Model Organisms

Danio rerio
slc13a3
Mus musculus
Slc13a3
Rattus norvegicus
Slc13a3
Saccharomyces cerevisiae
PHO90
Schizosaccharomyces pombe
SPBC3B8.04c

External links

OMIM
606411
Ensembl
ENSG00000158296
Entrez Gene
64849
UniGene
670365
1000 Genomes
1000 Genomes
HPRD
GenAtlas
SLC13A3
GeneCards
SLC13A3