The SLC52A1 gene and its putative association with human ageing

Cell Senescence Entries for SLC52A1

Cell Types: Osteosarcoma
Cell Lines: U2OS
Cancer Cell?: Yes
Method: Overexpression
Type of senescence: Stress-induced
Senescence Effect: Inhibits
Primary Reference: Nagano et al. (2018) Identification of cellular senescence-specific genes by comparative transcriptomics. Sci Rep 6(2)31758 (PubMed)

HGNC symbol: SLC52A1
Aliases: FLJ10060; GPCR42; GPR172B; hRFT1; PAR2; RFVT1
Common name: solute carrier family 52 member 1
Entrez Id: 55065
Description: Biological redox reactions require electron donors and acceptor. Vitamin B2 is the source for the flavin in flavin adenine dinucleotide (FAD) and flavin mononucleotide (FMN) which are common redox reagents. This gene encodes a member of the riboflavin (vitamin B2) transporter family. Haploinsufficiency of this protein can cause maternal riboflavin deficiency. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jan 2013].

Gene Ontology

Process:

GO:32218; riboflavin transport
GO:46718; viral entry into host cell
GO:6771; riboflavin metabolic process

Cellular component:

GO:16020; membrane
GO:16021; integral component of membrane
GO:5886; plasma membrane
GO:5887; integral component of plasma membrane

Function:

GO:32217; riboflavin transmembrane transporter activity
GO:5515; protein binding
GO:1618; virus receptor activity

Show all GO terms