Cell Senescence Entries for SLC5A2

Cell Types
Proximal tubular cell
Cell Lines
Primary cell
Cancer Cell?
No
Method
Knockdown
Type of senescence
Stress-induced
Senescence Effect
Induces
Primary Reference
Kitada et al. (2015) Hyperglycemia causes cellular senescence via a SGLT2- and p21-dependent pathway in proximal tubules in the early stage of diabetic nephropathy. J Diabetes Complications 28(5)604-11 (PubMed)

SLC5A2 Gene Information

HGNC symbol
SLC5A2 
Aliases
SGLT2 
Common name
solute carrier family 5 member 2 
Entrez Id
6524
Description
This gene encodes a member of the sodium glucose cotransporter family which are sodium-dependent glucose transport proteins. The encoded protein is the major cotransporter involved in glucose reabsorption in the kidney. Mutations in this gene are associated with renal glucosuria. Two transcript variants, one protein-coding and one not, have been found for this gene. [provided by RefSeq, Feb 2015].

SLC5A2 Ontologies

Gene Ontology
Process: GO:55085; transmembrane transport
GO:6811; ion transport
GO:6814; sodium ion transport
GO:8643; carbohydrate transport
GO:8645; hexose transmembrane transport
GO:5975; carbohydrate metabolic process
GO:98708; glucose import across plasma membrane
GO:17; alpha-glucoside transport
GO:98719; sodium ion import across plasma membrane
Cellular component: GO:16020; membrane
GO:16021; integral component of membrane
GO:5886; plasma membrane
GO:70062; extracellular exosome
Function: GO:22857; transmembrane transporter activity
GO:15293; symporter activity
GO:5412; glucose:sodium symporter activity
GO:55056; D-glucose transmembrane transporter activity
GO:15151; alpha-glucoside transmembrane transporter activity
GO:5362; low-affinity glucose:sodium symporter activity
Show all GO terms

Homologs of SLC5A2 in Model Organisms

Danio rerio
slc5a2
Mus musculus
Slc5a2
Rattus norvegicus
Slc5a2

External links

OMIM
182381
Ensembl
ENSG00000140675
Entrez Gene
6524
UniGene
709195
1000 Genomes
1000 Genomes
HPRD
GenAtlas
SLC5A2
GeneCards
SLC5A2