Cell Senescence Entries for SMAD5

Cell Types
Lung cancer
Cell Lines
NCI-H460
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Oncogene-induced
Senescence Effect
Induces
Primary Reference
Su et al. (2011) Role of p38 MAPK pathway in BMP4-mediated Smad-dependent premature senescence in lung cancer cells. Biochem J 433(2)333-43 (PubMed)

SMAD5 Gene Information

HGNC symbol
SMAD5 
Aliases
Dwfc; JV5-1; MADH5 
Common name
SMAD family member 5 
Entrez Id
4090
Description
The protein encoded by this gene is involved in the transforming growth factor beta signaling pathway that results in an inhibition of the proliferation of hematopoietic progenitor cells. The encoded protein is activated by bone morphogenetic proteins type 1 receptor kinase, and may be involved in cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014].

SMAD5 Ontologies

Gene Ontology
Process: GO:6355; regulation of transcription, DNA-templated
GO:7165; signal transduction
GO:45893; positive regulation of transcription, DNA-templated
GO:7179; transforming growth factor beta receptor signaling pathway
GO:90101; negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
GO:90287; regulation of cellular response to growth factor stimulus
GO:30154; cell differentiation
GO:9653; anatomical structure morphogenesis
GO:30509; BMP signaling pathway
GO:60395; SMAD protein signal transduction
GO:1901522; positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus
And 18 more GO terms
Cellular component: GO:5737; cytoplasm
GO:5634; nucleus
GO:5654; nucleoplasm
GO:5829; cytosol
GO:5667; transcription regulator complex
GO:785; chromatin
GO:32991; protein-containing complex
GO:71144; heteromeric SMAD protein complex
GO:71141; SMAD protein complex
Function: GO:5515; protein binding
GO:46872; metal ion binding
GO:3677; DNA binding
GO:981; DNA-binding transcription factor activity, RNA polymerase II-specific
GO:978; RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:1990837; sequence-specific double-stranded DNA binding
GO:31625; ubiquitin protein ligase binding
GO:70411; I-SMAD binding
GO:17151; DEAD/H-box RNA helicase binding
GO:977; RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:1227; DNA-binding transcription repressor activity, RNA polymerase II-specific
And 1 more GO terms
Show all GO terms

Homologs of SMAD5 in Model Organisms

Danio rerio
smad5
Mus musculus
Smad5
Rattus norvegicus
Smad5

External links

OMIM
603110
Ensembl
ENSG00000113658
Entrez Gene
4090
UniGene
167700
1000 Genomes
1000 Genomes
HPRD
GenAtlas
SMAD5
GeneCards
SMAD5