Cell Senescence Entries for SMARCA4

Cell Types
Mesenchymal stem
Cell Lines
Primary cell
Cancer Cell?
No
Method
Knockdown
Type of senescence
Replicative
Senescence Effect
Inhibits
Primary Reference
Alessio et al. (2010) The BRG1 ATPase of chromatin remodeling complexes is involved in modulation of mesenchymal stem cell senescence through RB-P53 pathways. Oncogene 29(40)5452-63 (PubMed)

SMARCA4 Gene Information

HGNC symbol
SMARCA4 
Aliases
BAF190; BRG1; FLJ39786; hSNF2b; SNF2; SNF2-BETA; SNF2L4; SNF2LB; SWI2 
Common name
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 
Entrez Id
6597
Description
The protein encoded by this gene is a member of the SWI/SNF family of proteins and is similar to the brahma protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. In addition, this protein can bind BRCA1, as well as regulate the expression of the tumorigenic protein CD44. Mutations in this gene cause rhabdoid tumor predisposition syndrome type 2. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012].

SMARCA4 Ontologies

Gene Ontology
Process: GO:6355; regulation of transcription, DNA-templated
GO:6325; chromatin organization
GO:6338; chromatin remodeling
GO:7399; nervous system development
GO:45944; positive regulation of transcription by RNA polymerase II
GO:45893; positive regulation of transcription, DNA-templated
GO:122; negative regulation of transcription by RNA polymerase II
GO:6357; regulation of transcription by RNA polymerase II
GO:45892; negative regulation of transcription, DNA-templated
GO:51091; positive regulation of DNA-binding transcription factor activity
GO:6337; nucleosome disassembly
And 22 more GO terms
Cellular component: GO:5634; nucleus
GO:5654; nucleoplasm
GO:5730; nucleolus
GO:1650; fibrillar center
GO:16514; SWI/SNF complex
GO:70603; SWI/SNF superfamily-type complex
GO:16020; membrane
GO:32991; protein-containing complex
GO:785; chromatin
GO:5615; extracellular space
GO:71564; npBAF complex
And 7 more GO terms
Function: GO:166; nucleotide binding
GO:5524; ATP binding
GO:16787; hydrolase activity
GO:4386; helicase activity
GO:16887; ATP hydrolysis activity
GO:42393; histone binding
GO:140658; ATP-dependent chromatin remodeler activity
GO:5515; protein binding
GO:70182; DNA polymerase binding
GO:3723; RNA binding
GO:3677; DNA binding
And 12 more GO terms
Show all GO terms

Homologs of SMARCA4 in Model Organisms

Caenorhabditis elegans
swsn-4
Danio rerio
smarca4
Mus musculus
Smarca4
Rattus norvegicus
Smarca4
Schizosaccharomyces pombe
snf22

External links

OMIM
603254
Ensembl
ENSG00000127616
Entrez Gene
6597
UniGene
327527
1000 Genomes
1000 Genomes
HPRD
GenAtlas
SMARCA4
GeneCards
SMARCA4