Cell Senescence Entries for SMARCB1

Cell Types
Malignant rhabdoid tumor
Cell Lines
G-401
Cancer Cell?
Yes
Method
Overexpression
Type of senescence
Unclear
Senescence Effect
Induces
Primary Reference
Oruetxebarria et al. (2004) P16INK4a is required for hSNF5 chromatin remodeler-induced cellular senescence in malignant rhabdoid tumor cells. J Biol Chem 279(5)3807-16 (PubMed)

SMARCB1 Gene Information

HGNC symbol
SMARCB1 
Aliases
BAF47; hSNFS; Ini1; PPP1R144; RDT; Sfh1p; SNF5; SNF5L1; Snr1 
Common name
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 
Entrez Id
6598
Description
The protein encoded by this gene is part of a complex that relieves repressive chromatin structures, allowing the transcriptional machinery to access its targets more effectively. The encoded nuclear protein may also bind to and enhance the DNA joining activity of HIV-1 integrase. This gene has been found to be a tumor suppressor, and mutations in it have been associated with malignant rhabdoid tumors. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2015].

SMARCB1 Ontologies

Gene Ontology
Process: GO:6338; chromatin remodeling
GO:7049; cell cycle
GO:6325; chromatin organization
GO:7399; nervous system development
GO:6357; regulation of transcription by RNA polymerase II
GO:45944; positive regulation of transcription by RNA polymerase II
GO:51091; positive regulation of DNA-binding transcription factor activity
GO:6337; nucleosome disassembly
GO:1188; RNA polymerase I preinitiation complex assembly
GO:1901838; positive regulation of transcription of nucleolar large rRNA by RNA polymerase I
GO:90240; positive regulation of histone H4 acetylation
And 21 more GO terms
Cellular component: GO:5634; nucleus
GO:228; nuclear chromosome
GO:70603; SWI/SNF superfamily-type complex
GO:43231; intracellular membrane-bounded organelle
GO:5654; nucleoplasm
GO:1650; fibrillar center
GO:32991; protein-containing complex
GO:785; chromatin
GO:5730; nucleolus
GO:16514; SWI/SNF complex
GO:71564; npBAF complex
And 8 more GO terms
Function: GO:3677; DNA binding
GO:5515; protein binding
GO:42802; identical protein binding
GO:3713; transcription coactivator activity
GO:3712; transcription coregulator activity
GO:2039; p53 binding
GO:31492; nucleosomal DNA binding
GO:1164; RNA polymerase I core promoter sequence-specific DNA binding
GO:30957; Tat protein binding
Show all GO terms

Homologs of SMARCB1 in Model Organisms

Caenorhabditis elegans
snfc-5
Danio rerio
smarcb1a
Drosophila melanogaster
Snr1
Mus musculus
Smarcb1
Rattus norvegicus
Smarcb1
Schizosaccharomyces pombe
sfh1

External links

OMIM
601607
Ensembl
ENSG00000099956
Entrez Gene
6598
UniGene
534350
1000 Genomes
1000 Genomes
HPRD
GenAtlas
SMARCB1
GeneCards
SMARCB1