Cell Senescence Entries for SMG1

Cell Types
Embryonic kidney, Retinal pigment epithelial
Cell Lines
HEK293T, HTERT-RPE1
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Lahtela et al. (2013) A high-content cellular senescence screen identifies candidate tumor suppressors, including EPHA3. Cell Cycle 12(4)625-34 (PubMed)

SMG1 Gene Information

HGNC symbol
SMG1 
Aliases
ATX; KIAA0421; LIP 
Common name
SMG1 nonsense mediated mRNA decay associated PI3K related kinase 
Entrez Id
23049
Description
This gene encodes a protein involved in nonsense-mediated mRNA decay (NMD) as part of the mRNA surveillance complex. The protein has kinase activity and is thought to function in NMD by phosphorylating the regulator of nonsense transcripts 1 protein. Alternatively spliced transcript variants have been described, but their full-length nature has yet to be determined. [provided by RefSeq, Mar 2013].

SMG1 Ontologies

Gene Ontology
Process: GO:184; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:16310; phosphorylation
GO:6281; DNA repair
GO:6974; cellular response to DNA damage stimulus
GO:18105; peptidyl-serine phosphorylation
GO:6406; mRNA export from nucleus
GO:46777; protein autophosphorylation
GO:6468; protein phosphorylation
GO:46854; phosphatidylinositol phosphate biosynthetic process
GO:31929; TOR signaling
GO:2001020; regulation of response to DNA damage stimulus
And 5 more GO terms
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:5654; nucleoplasm
GO:5829; cytosol
GO:33391; chromatoid body
GO:31931; TORC1 complex
GO:31932; TORC2 complex
Function: GO:3723; RNA binding
GO:46872; metal ion binding
GO:166; nucleotide binding
GO:4674; protein serine/threonine kinase activity
GO:4712; protein serine/threonine/tyrosine kinase activity
GO:5524; ATP binding
GO:16301; kinase activity
GO:16740; transferase activity
GO:106310; protein serine kinase activity
GO:5515; protein binding
GO:4672; protein kinase activity
And 3 more GO terms
Show all GO terms

Homologs of SMG1 in Model Organisms

Caenorhabditis elegans
smg-1
Danio rerio
smg1
Drosophila melanogaster
Smg1
Mus musculus
Smg1
Rattus norvegicus
Smg1

In other databases

GenAge model organism genes
  • A homolog of this gene for Caenorhabditis elegans is present as smg-1

External links

OMIM
607032
Ensembl
ENSG00000157106
Entrez Gene
23049
UniGene
460179
1000 Genomes
1000 Genomes
HPRD
GenAtlas
SMG1
GeneCards
SMG1